Protein Info for GFF3252 in Variovorax sp. SCN45

Annotation: Periplasmic chaperone and peptidyl-prolyl cis-trans isomerase of outer membrane proteins SurA (EC 5.2.1.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF13624: SurA_N_3" amino acids 59 to 172 (114 residues), 43.7 bits, see alignment E=6.7e-15 PF09312: SurA_N" amino acids 61 to 173 (113 residues), 76.4 bits, see alignment E=5.5e-25 PF13616: Rotamase_3" amino acids 202 to 307 (106 residues), 58.4 bits, see alignment E=2.6e-19 amino acids 317 to 416 (100 residues), 78 bits, see alignment E=2.2e-25 PF00639: Rotamase" amino acids 213 to 304 (92 residues), 63.8 bits, see alignment E=6.3e-21 amino acids 324 to 415 (92 residues), 80.3 bits, see alignment E=4.3e-26 PF13145: Rotamase_2" amino acids 328 to 423 (96 residues), 34.2 bits, see alignment E=9.8e-12

Best Hits

Swiss-Prot: 58% identical to SURA_RHOFT: Chaperone SurA (surA) from Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 87% identity to vpe:Varpa_5995)

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (465 amino acids)

>GFF3252 Periplasmic chaperone and peptidyl-prolyl cis-trans isomerase of outer membrane proteins SurA (EC 5.2.1.8) (Variovorax sp. SCN45)
MKHIRSIITLGCLAAMAASAGAQGFHSGITDIMRAGPRLGPPVARPAAPTTAPVQRAAEF
IVALVNSEPITNTEVLTRVDRLIKENPDAERVPRNELTRLVLDRLISERAQLQLAKENGI
KVDEVAIDQAEQTVARQNEISLTELRRRVIAEGLTQAEFRRDLRDQLLLTRLRDREVESK
VKISDAEADEYLIDQRNVAVKNAALQNLNLAQVLVAVPETATDAQVAAAQKKAQDIAQRA
RAGEDFAKLVRENSDAPDRANGGAIGMRSADRYPSLFVDATQSTAVNGIAGPIRSSAGFH
VLKVLAKAQIGSGDATVTQTQVRHILLLNDPKRTTAQAVAQLAEFKRRLQAGTADFAGLA
RDNSQDGSAKDGGELGWSRPGQFVPEFEEAMDRLAPGEISDPVVSRFGVHLIQVEGRRDA
KLTQSEQREAARAALREKRVEEAFSTWVQEVRARAYVEYREPPQS