Protein Info for GFF3246 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: ATP-dependent protease La (EC 3.4.21.53) Type II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 PF13654: AAA_32" amino acids 140 to 225 (86 residues), 51.2 bits, see alignment E=1.3e-17 PF05362: Lon_C" amino acids 435 to 540 (106 residues), 41.7 bits, see alignment E=1e-14

Best Hits

Swiss-Prot: 86% identical to LONH_ECOLI: Putative Lon protease homolog (ycbZ) from Escherichia coli (strain K12)

KEGG orthology group: K04770, Lon-like ATP-dependent protease [EC: 3.4.21.-] (inferred from 100% identity to stm:STM1068)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-, 3.4.21.53

Use Curated BLAST to search for 3.4.21.- or 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (586 amino acids)

>GFF3246 ATP-dependent protease La (EC 3.4.21.53) Type II (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
LTITKLAWRDLVPDSESYQEIFAQPHATDENDTLLSDTQPRLQFALEQLIQPWASSSFML
TKAPEEQEYLTLLSDAVRALQTDAGQLTGGHYDVSGHTVHYRAAQNAQDNFATVTQVVSA
DWVEAEQLFGCLRQYNGDITLQPGLVHQANGGVLIISLRTLLAQPLLWMRLKAIVSRERF
DWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELAEQAIYSEFEDNLQIAD
AEAMTLWCQWVTRIALRDNLPPPAPDAWPVLIREAVRYTGEQDTLPLCPLWIARQFKEAS
PLCEGDTCGAEALSLMLARREWREGFLAERMQDEILQEQILIETEGERVGQINALSVIEF
PGHPRAFGEPSRISCVVHIGDGEFNDIERKAELGGNIHAKGMMIMQAFLMSELQLEQQIP
FSASLTFEQSYSEVDGDSASMAELCALISALANVPVNQNIAITGSVDQFGRAQPVGGLNE
KIEGFFAICEQRELNGKQGVIIPAANVRHLSLKSELLQAVKEEKFTIWAVDDVTDALPLL
LNLVWDGEGQTTLMQTIQERIAQATQQEGRHRFPWPLRWLNAFIPN