Protein Info for GFF3243 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Catalase (EC 1.11.1.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00199: Catalase
  • amino acids 14 to 395 (382 residues), 616.7 bits, E=1.8e-189
• PF06628: Catalase-rel
  • amino acids 421 to 483 (63 residues), 61.4 bits, E=7.4e-21

Best Hits

Swiss-Prot: 79% identical to CATA_HAEIN: Catalase (katA) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03781, catalase [EC: 1.11.1.6] (inferred from 82% identity to abc:ACICU_01934)

Predicted SEED Role

"Catalase (EC 1.11.1.6)" in subsystem Oxidative stress or Photorespiration (oxidative C2 cycle) (EC 1.11.1.6)

MetaCyc Pathways

• reactive oxygen species degradation (4/4 steps found)
• ethanol degradation IV (3/3 steps found)
• superoxide radicals degradation (2/2 steps found)
• methanol oxidation to formaldehyde IV (1/2 steps found)

KEGG Metabolic Maps

• Methane metabolism
• Tryptophan metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.6

Use Curated BLAST to search for 1.11.1.6

Protein Sequence (509 amino acids)

>GFF3243 Catalase (EC 1.11.1.6) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MKDDAKRCPVTHLTTDFGAPVVTNRDSLTAGPRGPLLAQDVWLNEKLANFVREVVPERRM
HAKGSGAFGTFTVTKDITKYTRAKIFSEVGKKTDMFARFTTVAGERGAADAERDIRGFAL
KFYTEEGNWDMVGNNTPVFFVRDPRQFPDLNKAVKRDPRTNLRSARNNWDYWTLLPEALH
QVTVVMSDRGIPASYRHMHGFSSHTYSFWNQDGERFWVKLHFRTQQGIKNLTDAEAEALV
GKDRESHQRDLYDAIERGDFPKWTMYIQVMPELEAEQYRLHPFDLTKVWYKGDYPLIEVG
EFTLNKNPENFFLDVEQSAFSPSNLVPGIGVSPDRMLQARLFNYADAQRYRLGVNHQQIP
VNRARCPVHSNHRDGLGRVDDNYGGRPHYEPNSFGQWQAQPQFEEPPLKLTGAAKFWSYH
EDDNNYFEQPRKLFQLMSGAQKEALFGNTGRAMGDAPEFIKFRHIRNCHAADPAYGAGVA
KALGIDLVKALASKEADPMFDNSLVPLPA