Protein Info for GFF3214 in Variovorax sp. SCN45

Annotation: FIG138928: iron-regulated membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 159 to 181 (23 residues), see Phobius details amino acids 204 to 232 (29 residues), see Phobius details amino acids 364 to 386 (23 residues), see Phobius details amino acids 406 to 430 (25 residues), see Phobius details amino acids 446 to 464 (19 residues), see Phobius details amino acids 473 to 493 (21 residues), see Phobius details amino acids 505 to 527 (23 residues), see Phobius details PF03929: PepSY_TM" amino acids 10 to 387 (378 residues), 241.9 bits, see alignment E=6.7e-76

Best Hits

KEGG orthology group: None (inferred from 58% identity to rme:Rmet_1106)

Predicted SEED Role

"FIG138928: iron-regulated membrane protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (555 amino acids)

>GFF3214 FIG138928: iron-regulated membrane protein (Variovorax sp. SCN45)
MKEGFRQSMAWLHTWSGLLVGWVLFMVFAAGTASYFKDEITFWMKPELHAAAQPAVPPAR
AVESAVAYLQQRGADSPRWFINLPNERQPSTDVLWLAAPPSPAAAAASDGKDKKPPRRRF
DRASLDPATGEPVTAPRTTRGGEFLYRLHFDLHYMPALWARWIVGFCAMFMLVAIFSGIV
THKRIFKDFFTFRPKKGQRSWLDAHNVTAVLALPYHLMITYTGLVTLMFLYMPWGPQVAY
KDRGGEQAFFSEVFPGGGRDQVKASGNRVPLAPIAPMIAQASAHWNGAAVGRVTVHQPND
ANAVVSLTRAEGPQLSYDQPSMQFNGATGALIATFGDVPKPAAETRGVLYGLHIGRFANP
LLRALFFLSGIAGCLMVATGLLLWAVKERQKFAKTLKQGGRVSFGLRLVDGLNLGAIAGL
PLAMVAFFWANRLLPVEMAERGEAEIRWFFIVWGAAAVLGLLRPTLRMWQAQLSLGALLF
VLLPVLNAFTGPAPLTVSLRSGPSAVAGFDLVSIALGLGLASAVWLVERKRRKTIAQKQA
TKTPPQGLATSEGGS