Protein Info for PS417_16350 in Pseudomonas simiae WCS417

Annotation: competence protein ComEC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 737 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details transmembrane" amino acids 39 to 59 (21 residues), see Phobius details amino acids 226 to 246 (21 residues), see Phobius details amino acids 252 to 287 (36 residues), see Phobius details amino acids 298 to 317 (20 residues), see Phobius details amino acids 323 to 343 (21 residues), see Phobius details amino acids 355 to 375 (21 residues), see Phobius details amino acids 384 to 404 (21 residues), see Phobius details amino acids 411 to 431 (21 residues), see Phobius details amino acids 443 to 462 (20 residues), see Phobius details PF13567: DUF4131" amino acids 16 to 163 (148 residues), 122.7 bits, see alignment E=1.8e-39 TIGR00361: DNA internalization-related competence protein ComEC/Rec2" amino acids 104 to 710 (607 residues), 324.3 bits, see alignment E=1.3e-100 PF03772: Competence" amino acids 194 to 459 (266 residues), 187.7 bits, see alignment E=4.1e-59 TIGR00360: ComEC/Rec2-related protein" amino acids 215 to 393 (179 residues), 76.9 bits, see alignment E=2.3e-25 PF00753: Lactamase_B" amino acids 494 to 662 (169 residues), 56 bits, see alignment E=7.9e-19

Best Hits

KEGG orthology group: K02238, competence protein ComEC (inferred from 92% identity to pfs:PFLU3775)

Predicted SEED Role

"DNA internalization-related competence protein ComEC/Rec2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UB57 at UniProt or InterPro

Protein Sequence (737 amino acids)

>PS417_16350 competence protein ComEC (Pseudomonas simiae WCS417)
MFAFALGLLALRFLPALPPTGWLIALLVLALMLLPFRTYPLAFFLLGLSWACISAQWALD
DRLRPALEGQTRWVEGQVSGLPQQTGDGVRFVLTDSRSRNARLPKRIRVSWRGGPPVRSG
ERWRLAITLKRPAGLLNFHGFDQEAWLLAQRIGATGTVKDGERLAPATAAWRDSVRQRLL
AVDAQGREAGLIALVLGDGSGLAAADWQVLQDTGTVHLLVISGQHIGLLAGLIYGLIAGL
ARYGFWPRTWPWLPWACGLAFTTALGYGLLAGFGVPVQRACVMVGLVLLWRWRLRHLGLW
RPLLLALNGVLVLEPLASVQPGFWLSFAAVAVLILAFGGRLGPWSLWQAWTRPQWLIAIG
LFPVLLVLGLPISLSAPFANLVAVPWISLVVLPLALLGSALLVLPFVGEGLLWLAGGALD
ALFNGLAWLAGRMPAWIPAEVPPGYWLVSLLGATLLLLPKGVPFRVLGWPMLLLAVFPPR
APVPDGQVEVTQLDVGQGQSLILRTRHHTLLYDAGPRSGAFDLGARVVLPSLRKLGIGEL
DMLLLSHADADHAGGAAAIAKGMPIKRVVGGETEGLPISLGTQPCVSGERWTWDGVTFEL
WQWPDAISGNAKSCVLQVQAKGERLLLTGDIDRAAEQAMLASPLAVPTDWLQAPHHGSRS
SSSWPFVERLAPRSVLISRGRSNAFGHPHPQVMARYQRLGSQVYDSAEQGAVRLRLGAFA
APVVARSQRRFWRERLP