Protein Info for PS417_01605 in Pseudomonas simiae WCS417

Annotation: phosphoglycerate mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01676: Metalloenzyme
  • amino acids 6 to 497 (492 residues), 305.1 bits, E=4.1e-95
• TIGR01307: phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
  • amino acids 6 to 507 (502 residues), 766.8 bits, E=4.3e-235
• PF06415: iPGM_N
  • amino acids 84 to 295 (212 residues), 276.4 bits, E=1.5e-86

Best Hits

Swiss-Prot: 93% identical to GPMI_PSEPF: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K01834, phosphoglycerate mutase [EC: 5.4.2.1] (inferred from 98% identity to pfs:PFLU0337)

MetaCyc: 64% identical to 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Escherichia coli K-12 substr. MG1655)
3PGAREARR-RXN [EC: 5.4.2.12]

Predicted SEED Role

"2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.4.2.1)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/26 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
• gluconeogenesis I (11/13 steps found)
• Bifidobacterium shunt (12/15 steps found)
• glycolysis II (from fructose 6-phosphate) (9/11 steps found)
• glycolysis III (from glucose) (9/11 steps found)
• Rubisco shunt (8/10 steps found)
• glycolysis IV (8/10 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
• homolactic fermentation (9/12 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (14/19 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (19/26 steps found)
• ethene biosynthesis V (engineered) (18/25 steps found)
• glycolysis V (Pyrococcus) (7/10 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (19/27 steps found)
• superpathway of N-acetylneuraminate degradation (15/22 steps found)
• glycolysis VI (from fructose) (7/11 steps found)
• superpathway of hexitol degradation (bacteria) (12/18 steps found)
• photorespiration II (6/10 steps found)
• glycerol degradation to butanol (10/16 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (9/18 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (20/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.2.1 or 5.4.2.12

Sequence Analysis Tools

See A0A1N7U8T8 at UniProt or InterPro

Protein Sequence (508 amino acids)

>PS417_01605 phosphoglycerate mutase (Pseudomonas simiae WCS417)
MTTTPKPLVLIILDGFGHSESHHDNAVYAAKKPVLDRLTASVPNGLISGSGMDVGLPDGQ
MGNSEVGHMNLGAGRVVYQDFTRVTKAIRDGEFFENPTICAAVDKAVAAGKAVHFMGLLS
DGGVHSHQDHLVAMAELAFKRGADKIYLHAFLDGRDTPPKSAQSSIELLDTTFAALGKGR
IASLVGRYFAMDRDNRWDRVSQAYNLIVDGQAEFHAATAQEGLEAAYARGESDEFVKATT
IGEPVKVEDGDAVVFMNFRADRARELSRVFVEDGFKEFERARQPKVQYVGLTQYAASIPA
PAAFAPGSLDNVLGDYLAKNGKTQLRIAETEKYAHVTFFFSGGREEPFPGEERILIPSPK
VATYDLQPEMSAPEVTDKIVDAIEHQRYDVIVVNYANGDMVGHSGNLEAATKAVECLDLC
VGRIVDALEKVGGEALITADHGNCEQMSDESTGQAHTAHTTEPVPFIYVGKRDLKVREGG
VLADVAPTMLMLMGLEKPVEMTGTSILV