Protein Info for PS417_16075 in Pseudomonas simiae WCS417

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 304 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 40 to 60 (21 residues), see Phobius details amino acids 69 to 86 (18 residues), see Phobius details amino acids 107 to 125 (19 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 147 to 298 (152 residues), 91.9 bits, see alignment E=1.9e-30 PF00990: GGDEF" amino acids 148 to 298 (151 residues), 114.3 bits, see alignment E=2.4e-37

Best Hits

KEGG orthology group: None (inferred from 98% identity to pfs:PFLU3699)

Predicted SEED Role

"FIG160596: Signaling protein with membrane-bound sensor domain and GGDEF domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U4V2 at UniProt or InterPro

Protein Sequence (304 amino acids)

>PS417_16075 diguanylate cyclase (Pseudomonas simiae WCS417)
MFSVLKPHRWKLSLLLIAANLGLILHLACGELKSFSEWVWLDIVGEGGSALLALVWLGLV
LKSRPAGRVTNYLALGLSCIFFSWWIDSLDEFIRLPDSITWDHWLESGPMPVGMILLTIG
IYHWHREQLAISAQMEKRERLFREHRLFDKLTPLAGADYLKRQLADSLQDSHTQQQPLSL
LALDLDNFAAINQAYGHAEGDAVLQALSHLLLLNLRRQDLLCRLAGDRFVVLLPNTGERQ
AKALALELQQAVRGLAHKTRLHGERLQLAATTAVVMALNEPPHDLLKRLNLALARAKQPL
AKSA