Protein Info for PS417_01595 in Pseudomonas simiae WCS417

Annotation: peptidase S41

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF22694: CtpB_N-like" amino acids 42 to 92 (51 residues), 37.9 bits, see alignment 5e-13 TIGR00225: C-terminal processing peptidase" amino acids 62 to 382 (321 residues), 355.3 bits, see alignment E=1.6e-110 PF00595: PDZ" amino acids 107 to 175 (69 residues), 42.8 bits, see alignment E=1.4e-14 PF13180: PDZ_2" amino acids 108 to 179 (72 residues), 46.1 bits, see alignment E=1.2e-15 PF17820: PDZ_6" amino acids 123 to 177 (55 residues), 50.6 bits, see alignment 3.2e-17 PF03572: Peptidase_S41" amino acids 206 to 371 (166 residues), 196.4 bits, see alignment E=6.3e-62

Best Hits

KEGG orthology group: K03797, carboxyl-terminal processing protease [EC: 3.4.21.102] (inferred from 99% identity to pfs:PFLU0335)

Predicted SEED Role

"Carboxyl-terminal protease (EC 3.4.21.102)" (EC 3.4.21.102)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.102

Use Curated BLAST to search for 3.4.21.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U0Z2 at UniProt or InterPro

Protein Sequence (438 amino acids)

>PS417_01595 peptidase S41 (Pseudomonas simiae WCS417)
MLHLSRLTSLALTIALVIGAPLAFADQAAPAAPAATAATTKAPLPLDELRTFAEVMDRIK
AAYVEPVDDKTLLENAIKGMLSNLDPHSAYLGPEDFAELQESTSGEFGGLGIEVGSEDGN
IKVVSPIDDTPASKAGIQAGDFIVKINGQPTRGQTMTEAVDKMRGKIGQKITLTLVRDGG
NPFDVTLTRATILVKSVKSQLLESGYGYIRITQFQVKTGDEVAKALAKLRKDNGKKLNGI
VLDLRNNPGGVLQSAVEVVDHFITKGLIVYTKGRIANSELRFSATGNDLSENVPLAVLIN
GGSASASEIVAGALQDQKRGVLMGTTSFGKGSVQTVLPLNNERALKITTALYYTPNGRSI
QAQGIVPDIEVRKAKITNEIDSEYYKEADLQGHLGNGNGGADQPTDSSKKAKPMPQDDDY
QLAQALSLLKGLSITRSR