Protein Info for GFF3127 in Xanthobacter sp. DMC5

Annotation: Transcriptional regulatory protein CusR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 PF00072: Response_reg" amino acids 16 to 125 (110 residues), 88.8 bits, see alignment E=2.7e-29 PF00486: Trans_reg_C" amino acids 158 to 232 (75 residues), 102.8 bits, see alignment E=8.1e-34

Best Hits

Swiss-Prot: 50% identical to CUSR_ECOL6: Transcriptional regulatory protein CusR (cusR) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02483, two-component system, OmpR family, response regulator (inferred from 97% identity to xau:Xaut_3517)

Predicted SEED Role

"response regulator in two-component regulatory system with PhoQ" in subsystem Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (238 amino acids)

>GFF3127 Transcriptional regulatory protein CusR (Xanthobacter sp. DMC5)
MTTNLDPGPLSAMRLLLVEDDRDAAEYLRKAFREAGHVVDHAADGEEGLALALDGKYDVM
VVDRMLPARDGLSLVTELRGRGHTTPVLILSALGQVDDRVQGLRAGGDDYLPKPYAFTEL
LARVEALSRRGVSQGAETVYKVADLELDRLAHRVTRSGKEIQLQPREFRLLEYLMRHAGQ
VVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRAGLA