Protein Info for GFF3124 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: NADPH-dependent broad range aldehyde dehydrogenase YqhD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00465: Fe-ADH
  • amino acids 9 to 366 (358 residues), 311.3 bits, E=7.8e-97
• PF13685: Fe-ADH_2
  • amino acids 31 to 109 (79 residues), 29.5 bits, E=6.4e-11

Best Hits

Swiss-Prot: 89% identical to YQHD_ECOLI: Alcohol dehydrogenase YqhD (yqhD) from Escherichia coli (strain K12)

KEGG orthology group: K08325, NADP-dependent alcohol dehydrogenase [EC: 1.1.-.-] (inferred from 99% identity to spt:SPA3032)

MetaCyc: 89% identical to NADPH-dependent aldehyde reductase YqhD (Escherichia coli K-12 substr. MG1655)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]

Predicted SEED Role

No annotation

MetaCyc Pathways

• methylglyoxal degradation III (2/2 steps found)
• 1,3-propanediol biosynthesis (engineered) (7/9 steps found)
• superpathway of methylglyoxal degradation (6/8 steps found)
• glycerol degradation to butanol (11/16 steps found)
• D-xylose degradation to ethylene glycol (engineered) (2/4 steps found)
• D-arabinose degradation V (1/3 steps found)
• pyruvate fermentation to butanol I (4/8 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
• detoxification of reactive carbonyls in chloroplasts (1/10 steps found)
• superpathway of pentose and pentitol degradation (17/42 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Benzoate degradation via CoA ligation
• Bisphenol A degradation
• Caprolactam degradation
• Ethylbenzene degradation
• Fructose and mannose metabolism
• Galactose metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Limonene and pinene degradation
• Naphthalene and anthracene degradation
• Pentose and glucuronate interconversions
• Pyruvate metabolism
• Retinol metabolism
• gamma-Hexachlorocyclohexane degradation

Isozymes

Compare fitness of predicted isozymes for: 1.1.-.-

Use Curated BLAST to search for 1.1.-.- or 1.1.1.2 or 1.1.1.21

Protein Sequence (387 amino acids)

>GFF3124 NADPH-dependent broad range aldehyde dehydrogenase YqhD (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNNFKLHTPTRILFGKGAIVDLRDQIPQDARVLITYGGGSVKKTGVLAQVQEALKGLDVR
EFGGIEPNPSYETLMKAVQLVRDENITFLLAVGGGSVLDGTKFIAAAAQYTDGVDPWHIL
ETGGTEIRSAIPMGSVLTLPATGSESNAGAVISRKTTGDKQAFHSSFVQPVFAVLDPVYT
YTLPPRQVANGVVDAFVHTVEQYVTYPVNGKIQDRFAEGILLTLIEEGPKALQEPENYDV
RANVMWAATQALNGLIGAGVPQDWATHMLGHELTAMHGLDHAQTLAIVLPALWNEKRDVK
RAKLLQYAERVWNITDGSDDERIDAAIAATRRFFEQMGVPTHLSDYGLDGSTIPALLAKL
EAHGCINLGENQDITLDVSRRIYEAAR