Protein Info for GFF3107 in Variovorax sp. SCN45

Annotation: Oxidoreductase, aldo/keto reductase family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 PF00248: Aldo_ket_red" amino acids 17 to 310 (294 residues), 219.1 bits, see alignment E=3.5e-69

Best Hits

Swiss-Prot: 46% identical to AKR2_ORYSI: Probable aldo-keto reductase 2 (OsI_15387) from Oryza sativa subsp. indica

KEGG orthology group: None (inferred from 82% identity to bph:Bphy_3317)

MetaCyc: 42% identical to perakine reductase (Rauvolfia serpentina)
RXN-12673 [EC: 1.1.1.317]

Predicted SEED Role

"Aldo-keto reductase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.317

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (336 amino acids)

>GFF3107 Oxidoreductase, aldo/keto reductase family (Variovorax sp. SCN45)
MNTLQLGATGPKVSAFGLGCMGMSGMYGPADRAESIATIHAAMDAGITLLDTGDFYGSGH
NEMLIGEALKGLKGSQRDAALVSVKFGAMRDPAGGWVGYDARPAAVKNFATYSLQRLGVD
HIDVYRPARLDPNVPVEDTIGAIADLVKAGYVRHIGLSEVGSQTIRKAAAVHPVCDLQIE
YSLISRGIEDDILATCRELGIAITAYGVLSRGLISGHWKKDSAGAKDFRAHSPRFQGENV
DRNLALVDALRKIADAKGVTVAQIAIAWVVAQGDDIVPLIGARQRTRLDEALGALDVKLS
ADDLAAIERAVPKGAAAGDRYAAAQMASLDSEPRRG