Protein Info for GFF3105 in Variovorax sp. SCN45

Annotation: Tas protein, an NADP(H)-dependent aldo-keto reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 392 PF00248: Aldo_ket_red" amino acids 54 to 383 (330 residues), 225.6 bits, see alignment E=3.6e-71

Best Hits

Swiss-Prot: 42% identical to TAS_SHIFL: Protein tas (tas) from Shigella flexneri

KEGG orthology group: None (inferred from 90% identity to vap:Vapar_3774)

Predicted SEED Role

"Oxidoreductase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (392 amino acids)

>GFF3105 Tas protein, an NADP(H)-dependent aldo-keto reductase (Variovorax sp. SCN45)
MAPDDKEALAGAQSATGQAPPGFIAPGQREAGGDGSIPRMKKIQLGQSDLHVTPICLGTM
TFGEQVDEPTSHAILSRSLERGVDFIDTAEMYSVPTRKETYTVTETIIGNWFAANPGARE
KLVVATKVAGPSRGMPWVREGSGMTAADIEASCNASLKRLKTDVIDLYQIHWPERHVPLF
GNMYYDPAKESSKTPILEQLEALGKLVKAGKVRAIGLSNETPYGVHEFVRLAEQHGLPRV
ATVQNVYSLISRGHENALDETMHRLNVSLLAYSPLAFGLLTGKYDQSGIEGPDAPKGARI
SSYESVRKQRWGRPDSLRAAKRYNQLARDNGLTPTQLALAFCYTKWQVASTIIGVTSVAQ
LDEDLDAYGTTLSAEILAEIDKIRWEIRDPAA