Protein Info for GFF3102 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: [NiFe] hydrogenase nickel incorporation protein HybF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01155: HypA
  • amino acids 1 to 112 (112 residues), 119 bits, E=5.3e-39
• TIGR00100: hydrogenase nickel insertion protein HypA
  • amino acids 1 to 113 (113 residues), 144.3 bits, E=7.9e-47

Best Hits

Swiss-Prot: 100% identical to HYBF_SALTI: Hydrogenase maturation factor HybF (hybF) from Salmonella typhi

KEGG orthology group: K04651, hydrogenase nickel incorporation protein HypA (inferred from 99% identity to sed:SeD_A3492)

MetaCyc: 49% identical to hydrogenase 3 nickel incorporation protein HypA (Escherichia coli K-12 substr. MG1655)
RXN-22650

Predicted SEED Role

"[NiFe] hydrogenase nickel incorporation protein HybF" in subsystem NiFe hydrogenase maturation

MetaCyc Pathways

• NiFe(CO)(CN)₂ cofactor biosynthesis (9/10 steps found)

Protein Sequence (113 amino acids)

>GFF3102 [NiFe] hydrogenase nickel incorporation protein HybF (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MHELSLCQSAVEIIQQQAEQHGVARVTGVWLEIGALSCVEERAVRFSFDIACQGTLAQGC
ELHIDYRPAQAWCWDCSQVVEILRHDAQCPHCHGDRLRVDTGDSLKVKSIEVE