Protein Info for PS417_15700 in Pseudomonas simiae WCS417

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 271 PF13145: Rotamase_2" amino acids 96 to 227 (132 residues), 38.4 bits, see alignment E=3.1e-13 PF13616: Rotamase_3" amino acids 117 to 215 (99 residues), 66.1 bits, see alignment E=6.4e-22 PF00639: Rotamase" amino acids 121 to 214 (94 residues), 74.3 bits, see alignment E=1.9e-24

Best Hits

KEGG orthology group: K03769, peptidyl-prolyl cis-trans isomerase C [EC: 5.2.1.8] (inferred from 85% identity to pba:PSEBR_a3144)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See U1UNY3 at UniProt or InterPro

Protein Sequence (271 amino acids)

>PS417_15700 peptidylprolyl isomerase (Pseudomonas simiae WCS417)
MTQPELIASSEQEWPIVSVNGVSITPEAMALELQYHPAESREAAVYLAARALVIRELLQQ
RITELGLAVDIAPGENEEEAATRLLLEREITVPQCDEATCRHYFESNRGRFHSAPLLAVR
HILLECAPDDAEARQMAHVQAEILQLSLAQTPASFAELALKYSACPSKAQGGSLGQISKG
QTVPELERQLFTLAPGLADKPLESRYGWHVISVDQRIEGQPLPYEAVAGAIRTQLQQGVW
QKALVQYLQTLIGAADIRGLALQGADSPLVQ