Protein Info for GFF3060 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Lysine 2-monooxygenase (EC 1.13.12.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 562 PF13450: NAD_binding_8" amino acids 47 to 114 (68 residues), 37.2 bits, see alignment E=3e-13 PF01593: Amino_oxidase" amino acids 52 to 531 (480 residues), 145.7 bits, see alignment E=2.7e-46

Best Hits

KEGG orthology group: K00466, tryptophan 2-monooxygenase [EC: 1.13.12.3] (inferred from 77% identity to pfl:PFL_5670)

MetaCyc: 74% identical to L-lysine monooxygenase monomer (Pseudomonas putida)
Lysine 2-monooxygenase. [EC: 1.13.12.2]

Predicted SEED Role

"Lysine 2-monooxygenase (EC 1.13.12.2)" in subsystem Lysine degradation (EC 1.13.12.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.12.2 or 1.13.12.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (562 amino acids)

>GFF3060 Lysine 2-monooxygenase (EC 1.13.12.2) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MPTPLRGADAPVTLFGPDFPFAFDDWIAHPQGLGELPAERLGQEVAIVGAGMAGMVAAYE
LMKLGLKPVVYEASRMGGRLRSQAFEGGQGAIAELGGMRFPASSTAFFHYVNRLGLKTQP
FPNPLTPAAGCTVIDLEGRTHWGRTLADLPPLFSEVAAAWAQALEEGAGFTGLQQALRER
DAGQLKALWNRLVPLWDDRTFYDFVATSKAFSRLSFLHREVFGQVGFGTGGWDSDFPNSM
LEILRVVLTGCDENQHLIVGGVQQVPLGLWHHAPAANELRHWPAGTTLASLHHGAPRPGV
TAIARAASNELAVTDTWGNTRSYPAVLTTCQSWLLTTQIAVEEALFSQKHWMALDRTRYM
QSSKTFVMVDRAFWNDLREEGERKGWPQMGMTLTDRLTRGTYLFDNGPDQPGVICLSYAW
MGDALKMLPHGTKKRVQLALQALEKIYPDVDIASHIIGDPISVSWEADPHFLGAFKGALP
GHYRYNHRMYSHFMQDGFAAAERGIFLAGDDVSFTPAWVEGAVQTSLNAVWGIVKHLGGR
THADNPGPGDVFAELGPMALPD