Protein Info for GFF3035 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: D-mannonate oxidoreductase (EC 1.1.1.57)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 53% identical to UXUB_ECOLI: D-mannonate oxidoreductase (uxuB) from Escherichia coli (strain K12)
KEGG orthology group: None (inferred from 99% identity to seh:SeHA_C3321)MetaCyc: 53% identical to D-mannonate oxidoreductase (Escherichia coli K-12 substr. MG1655)
Fructuronate reductase. [EC: 1.1.1.57]
Predicted SEED Role
"D-mannonate oxidoreductase (EC 1.1.1.57)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.57)
MetaCyc Pathways
- D-fructuronate degradation (4/4 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- superpathway of hexuronide and hexuronate degradation (8/10 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.57
Use Curated BLAST to search for 1.1.1.57
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (490 amino acids)
>GFF3035 D-mannonate oxidoreductase (EC 1.1.1.57) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MDTIARQLDAARHQFKTTYSRQGMEANIVHIGFGAFHRGHQAVYNDLTNEITGNRWGIFE LNLFGDAELVDALNAQQGLFSVVETSASAINSRLVRTITGALHTPKSGIQAAIEKLTEPQ VKIVSLTITEKGYCTDPRSRTLDLSHPLIKHDLADPEHPRSALGLIVEALRIRRQQGLPP FSVLSCDNIPENGHLTKTAIVTFADNLDPQLAAWIAKHVTFPGTMVDRIVPAMTPEQFDM IKDQIGFADPCGIVCEDFRQWVIEDNFVAGRPDWDKAGAMFVSDVLPYEEMKLRMLNGSH SFLAYNGSLAGYEFIYQCMEDDAFKTAVHHLMTEEQAKSLRPNLAVDVHQYAQLLIDRFS NPNIKHKTGQIAMDGSQKLPQRAVDPYLTLQARGVKGRALATLIAGWLHYVINTLSQGQS VADPLNDTFNAAIKNKNTRWEQALSLLQINSIFGTLASDNADFLNNIQQAFNHIELHGVT ATIHRLSSKG