Protein Info for GFF2997 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: COG1272: Predicted membrane protein hemolysin III homolog

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 54 to 74 (21 residues), see Phobius details amino acids 86 to 105 (20 residues), see Phobius details amino acids 111 to 132 (22 residues), see Phobius details amino acids 139 to 159 (21 residues), see Phobius details amino acids 165 to 187 (23 residues), see Phobius details amino acids 196 to 216 (21 residues), see Phobius details PF03006: HlyIII" amino acids 12 to 209 (198 residues), 130.7 bits, see alignment E=3.4e-42 TIGR01065: channel protein, hemolysin III family" amino acids 15 to 216 (202 residues), 238 bits, see alignment E=3.5e-75

Best Hits

Swiss-Prot: 91% identical to YQFA_ECOL6: UPF0073 inner membrane protein YqfA (yqfA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K11068, hemolysin III (inferred from 100% identity to seh:SeHA_C3281)

Predicted SEED Role

"COG1272: Predicted membrane protein hemolysin III homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (219 amino acids)

>GFF2997 COG1272: Predicted membrane protein hemolysin III homolog (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MVQKPLMTQGYSLAEEIANSISHGIGLVFGIVGLVLLLVQAVEANAGMTAIASYSLYGGS
MILLFLASTLYHAIPHQRAKIWLKKFDHCAIYLLIAGTYTPFLLVGLDSPLARGLMIVIW
SLALFGILFKLTIAHRFKVLSLVTYLAMGWLSLIVVYQLAIKLAIGGVTLLAVGGVVYSL
GVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYVGQA