Protein Info for GFF2961 in Variovorax sp. SCN45

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1073 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 331 to 351 (21 residues), see Phobius details amino acids 358 to 378 (21 residues), see Phobius details amino acids 384 to 405 (22 residues), see Phobius details amino acids 429 to 450 (22 residues), see Phobius details amino acids 456 to 476 (21 residues), see Phobius details amino acids 538 to 558 (21 residues), see Phobius details amino acids 887 to 907 (21 residues), see Phobius details amino acids 915 to 935 (21 residues), see Phobius details amino acids 942 to 966 (25 residues), see Phobius details amino acids 990 to 1010 (21 residues), see Phobius details amino acids 1022 to 1045 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1045 (1045 residues), 673.3 bits, see alignment E=5.9e-206 PF03176: MMPL" amino acids 839 to 1048 (210 residues), 30 bits, see alignment E=2.7e-11

Best Hits

KEGG orthology group: None (inferred from 68% identity to bcj:BCAM1421)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1073 amino acids)

>GFF2961 CzcABC family efflux RND transporter, transmembrane protein (Variovorax sp. SCN45)
MVQLALRRPYTFIVMAMLIVLATPFVLARMATDIFPEINIPVVSVIWNYTGLPAQEMGQR
ISGQVERGLTTTVSDIEHIESQSLAGVSIIKVFFQPTANIEMAISQVVASMQAQVRQLPP
GITPPLVIKYSASSVPVIQLALSSPTRSENSLFDATVNQLRPQLITVPGAAIPFPYGGKN
RLISVDLDTQALQARGLSPADVVNAVNTQNLILPSGTAKFGATEYNVKMNGSPDAIAGLN
DLPIRTVNGATTYLRDVAYVRDGFSPQTNVVRQDGVRGVLLSVLKNGGASTLDIVSNIRA
MLPIAAQTMPEDIKITPLFDQSVFVKAAVKGVVFEAILAAALTAAMVLLFLGNWRSTLII
GLTIPLSILASILVLYSLGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHMGTPLKD
AIEVGAGEIGSAAFVSTLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMIASYLLSRTLV
PTLVMLLMGGSHGPQQQQPAEGTRQSALQRLYRAFDRRFERVRRAYTLVLSAVLSRRAGF
IGLFLGFCLLSCLLYPVLGRDFFPTVDAGQIRLHLRAPTGTRIEETARLTDQVEAAIREL
VPPDQLETILDNLGVPNSGINLSYSNAGTIGTFDGELLLSLKEGHKPTEQHVSLLRAELP
KRFPGIEFFFQPADIVTQILNFGLPAAIDVQFSGNDMAGNAARAAELTKAIRQIPGAVDA
HVHQRLDGPALSLQMDRTRLQQYGLTASNVGQNVLIALSGSSQTAPAFWLNPANGVVYSI
AVQTPQYTVDSLDSLLNIPVGASGGQGGTGAQQLLGNLVSTQADRQPAVMSRYNIAPVID
VYVSVQGTDLASVASKVQKLVDEMRPKLSRGSRVDIRGQVQTMQSSFIGLGVGLAMAIVL
VYLLIVVTFQSWLDAAIIITALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVATANSI
LLVSFARERLQAGIPPLSAALEAGATRIRPVLMTALAMIIGMIPMALGLGEGAEQNAPLG
RAVIGGLVFATVSTLFFVPAVFAGVHSRLARRRAAREASQQHQPPEGATPQEN