Protein Info for PS417_15115 in Pseudomonas simiae WCS417

Annotation: exonuclease SbcD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 413 PF00149: Metallophos" amino acids 1 to 232 (232 residues), 51.6 bits, see alignment E=1.7e-17 TIGR00619: exonuclease SbcCD, D subunit" amino acids 1 to 259 (259 residues), 173 bits, see alignment E=4.9e-55 PF12320: SbcD_C" amino acids 283 to 385 (103 residues), 60.4 bits, see alignment E=1.9e-20

Best Hits

KEGG orthology group: K03547, exonuclease SbcD (inferred from 96% identity to pfs:PFLU3512)

Predicted SEED Role

"Exonuclease SbcD" in subsystem DNA repair, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U7G1 at UniProt or InterPro

Protein Sequence (413 amino acids)

>PS417_15115 exonuclease SbcD (Pseudomonas simiae WCS417)
MRLFHTSDWHLGQNLHGQERDFEHACFLEWLLGQLKTHLPDVLLIAGDIFDTVNPPLKAQ
ERLYDFIISAHEQNPKLTIVMIAGNHDSGSRIELPAPLMRRLRTHALGRVLWLDDGQLDA
ERLLIPLPDAKGKIAAWCLALPFLRPAEVTGAHLGDDYLRGIGQVHEWLIAAANAKRKKG
QALIAISHAHMAGGSVSEDSERSLIIGNAEALPASLFDRSVAYVALGHLHKPQKVNGEER
IRYSGSPIPLSFSEIGYKHQILDVTFQGQCLVSVEPLLIPRSVDLQRLEAAPLADILKAL
AELPDIDLLAETQRHPWLEVRVRLDEPQPDLRQQIESALQGKAVRLVRIAAEYAGTGSRE
DEGDDRLIDLDQLTPQELFSRAWQDSYGSDVDEQTLKDFAVLLQEVQQEGEQP