Protein Info for GFF2899 in Xanthobacter sp. DMC5

Annotation: Cardiolipin synthase A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 transmembrane" amino acids 6 to 28 (23 residues), see Phobius details amino acids 39 to 58 (20 residues), see Phobius details TIGR04265: cardiolipin synthase" amino acids 7 to 481 (475 residues), 319.1 bits, see alignment E=2.9e-99 PF13396: PLDc_N" amino acids 19 to 59 (41 residues), 44.6 bits, see alignment 1.7e-15 PF13091: PLDc_2" amino acids 132 to 247 (116 residues), 40.5 bits, see alignment E=3.6e-14 amino acids 323 to 443 (121 residues), 101.8 bits, see alignment E=4.1e-33

Best Hits

KEGG orthology group: K06131, cardiolipin synthase [EC: 2.7.8.-] (inferred from 85% identity to xau:Xaut_0946)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (481 amino acids)

>GFF2899 Cardiolipin synthase A (Xanthobacter sp. DMC5)
MQDSAVIAWVFYVAHLSLQIIFAIRALLRPHREPASRMAWVLVILLAPVVGMLAYVLFGE
VNLGRKAVESLRAAVRALPPAEGVAGPSAEADIPERHVPLFRVGQSVNHFLPVAGNRAEL
LPDSASAIAAMVRDIDGARQSVHVLFYIWLDDASGRLVMEALKRAAARGVTCRAMADDLG
SRALIRSAFWRDMAAAGVRLATALPIGNPLLRPFKGRIDMRNHRKIVVIDNAITYCGSQN
CADAAFAVKAKFAPWVDVMARFEGPVVRQNQHLFASNWMAQVEEDLAPLFAEPLPPQQPG
FVAQVIGSGAGVRYSAMPEMFVALMNAARRELVITTPYYVPDEPLQAALCSAARRGVATT
IVFPRRNDSWIVAAASRSYYHELLEAGVEIREYVGGLLHAKTLTLDGEMTLIGSANIDRR
SFELNAENNILLYDPAFTRTLRERQQVFLDAATPVTQDDADAYSAPRRLWNNTIAMLGPV
L