Protein Info for GFF2879 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Two-component hybrid sensor and regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1141 transmembrane" amino acids 51 to 75 (25 residues), see Phobius details amino acids 81 to 103 (23 residues), see Phobius details amino acids 124 to 149 (26 residues), see Phobius details amino acids 155 to 177 (23 residues), see Phobius details amino acids 188 to 205 (18 residues), see Phobius details amino acids 225 to 245 (21 residues), see Phobius details amino acids 265 to 293 (29 residues), see Phobius details amino acids 318 to 338 (21 residues), see Phobius details amino acids 367 to 388 (22 residues), see Phobius details amino acids 395 to 413 (19 residues), see Phobius details amino acids 434 to 455 (22 residues), see Phobius details amino acids 461 to 483 (23 residues), see Phobius details amino acids 576 to 596 (21 residues), see Phobius details amino acids 611 to 631 (21 residues), see Phobius details PF00512: HisKA" amino acids 677 to 743 (67 residues), 58.1 bits, see alignment 1.1e-19 PF02518: HATPase_c" amino acids 791 to 899 (109 residues), 89.2 bits, see alignment E=3.7e-29 PF00072: Response_reg" amino acids 930 to 1040 (111 residues), 70.8 bits, see alignment E=1.6e-23

Best Hits

KEGG orthology group: None (inferred from 73% identity to aaa:Acav_0234)

Predicted SEED Role

"Two-component hybrid sensor and regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1141 amino acids)

>GFF2879 Two-component hybrid sensor and regulator (Hydrogenophaga sp. GW460-11-11-14-LB1)
MPSPEPARPVATQKIFRFRREYNSWVADETMEDYALRYTPRSFRKWSEWRVANTAFGSLS
FLALEAIGGAIAVNYGFANAMWAILVVGLVIFFTSLPIAYYAARYGLDMDLLTRGAGFGY
LGSTITSLIYAVFTFIFFAIEAVIMALALQMATDWPLAWCYLISAVVIVPLVIRGITLIS
RLQAWTQPLYLFLLLLPFVWIGLSQPQLYRDFTSLTGIRSGSSEFHPLMFGAAAAVIFSL
VVQIGEQVDFLRFMPERTRQNRVRWWLAVLIPGPGWIVMGMLKMVGGAFLAFAAMQFEVD
PERTAEPTQMFLAGFTEAVGHPGLAVAMTVVFVILAQVKINVTNAYAGSLAWSNFFARVT
HSHPGRVVWLVFNVCIATLLMLLGVFTGLEKVLGVYSNVAIAWVGALVADLIINKPLGLS
PRGIEFRRAYLYDFNPVGMGSMIIAALVASLAYAGVMGEVAAAFSPFIALGLALVLAPLI
AWATRGRYYLARTPSHEWKPGEVVRCSVCENQFESEDMAGCPAYQAPICSLCCSLESRCH
DRCKTNSRAIDQVRAALAAVLPQGAMVRVNFRAGQFLAVWLSLSAIMAFLIGMVYLQESL
HAPAEALQSPFLKIFAFLVLLAAVCAWWVVLTTDSRRMAQDESERQTQLLMLEIDAHQRT
DAELQSARDRAETASQAKTRYVAGMTHELRTPLTSILGYAQILLKNSEISVWVRETIATM
QRSGQHMHALIDGSLDLARIEAGRLKLDPVPLPLGQLLEDVERMVRPQAEAKGLRFVVQQ
EGELPTWVRADAKRLRQILINLLSNAVRFTDEGEVTLRLDFRQQVARIDVIDTGIGIAAQ
DQKRIFLPFERGSAGRRAADTGTGLGLTITHLLTDMMGGELLLKSRPGHGSTFSLRLYLP
PIPSDPKHPLPIPSTLRAVTGYLGERRTLLVVDDQPLHRQLLASILVPLGFVVREAASGQ
ECLEIIEQHAPDGLLLDLTMDGLDGWQTAAAVRKLLPASRLPIVFVSANLFDNRPEQLTA
LDCQGFVAKPMMESELLDALKHALALEWVTEQAPAAAPVSFVRHRVSGLPLPEDLREELQ
RLARQGQAAALRQRLWQAQTAEPAHAATLALLQSCADRFDFQTLIEYLRDTAELTEDDID
T