Protein Info for GFF2833 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: PTS system, mannose-specific IID component (EC 2.7.1.69)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 283 transmembrane" amino acids 130 to 155 (26 residues), see Phobius details amino acids 188 to 206 (19 residues), see Phobius details amino acids 237 to 255 (19 residues), see Phobius details amino acids 262 to 281 (20 residues), see Phobius details TIGR00828: PTS system, mannose/fructose/sorbose family, IID component" amino acids 11 to 281 (271 residues), 487.5 bits, see alignment E=5.1e-151 PF03613: EIID-AGA" amino acids 12 to 281 (270 residues), 367.8 bits, see alignment E=1.4e-114

Best Hits

Swiss-Prot: 93% identical to PTND_ECO57: PTS system mannose-specific EIID component (manZ) from Escherichia coli O157:H7

KEGG orthology group: K02796, PTS system, mannose-specific IID component (inferred from 100% identity to sek:SSPA0971)

MetaCyc: 93% identical to mannose-specific PTS enzyme IID component (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-157 [EC: 2.7.1.199]; 2.7.1.199 [EC: 2.7.1.199]; TRANS-RXN-167 [EC: 2.7.1.199, 2.7.1.193]; TRANS-RXN-165 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]; 2.7.1.191 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]

Predicted SEED Role

"PTS system, mannose-specific IID component"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.191 or 2.7.1.193 or 2.7.1.199

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (283 amino acids)

>GFF2833 PTS system, mannose-specific IID component (EC 2.7.1.69) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MVDMTKTTTEKKLTPSDIRGVFLRSNLFQGSWNFERMQALGFCFSMVPAIRRLYPENNDA
RKQAIKRHLEFFNTHPYVAAPVLGVTLAMEEKRANGAEIDDGAINGIKVGLMGPLAGVGD
PIFWGTVRPVFAALGAGIAMSGSLLGPLLFFILFNLVRLATRYYGVAYGYRKGVDIVKDM
GGGFLQKLTEGASILGLFVMGALVNKWTHVNIPLVVSTITGQDGQTRVTTVQTILDQLMP
GLVPLLLTFACMWLLRKKVNPLWIIVGFFVIGIAGYSVGLLGQ