Protein Info for GFF2832 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: PTS system, mannose-specific IIC component (EC 2.7.1.69)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 94% identical to PTNC_ECO57: PTS system mannose-specific EIIC component (manY) from Escherichia coli O157:H7

KEGG orthology group: K02795, PTS system, mannose-specific IIC component (inferred from 97% identity to ent:Ent638_2387)

MetaCyc: 94% identical to mannose-specific PTS enzyme IIC component (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-157 [EC: 2.7.1.199]; 2.7.1.199 [EC: 2.7.1.199]; TRANS-RXN-167 [EC: 2.7.1.199, 2.7.1.193]; TRANS-RXN-165 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]; 2.7.1.191 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]

Predicted SEED Role

No annotation

MetaCyc Pathways

superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (24/26 steps found)
superpathway of glycolysis and the Entner-Doudoroff pathway (17/17 steps found)
glycolysis I (from glucose 6-phosphate) (13/13 steps found)
D-mannose degradation I (2/2 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.191 or 2.7.1.193 or 2.7.1.199

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (266 amino acids)

>GFF2832 PTS system, mannose-specific IIC component (EC 2.7.1.69) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MEITTLQIVLVFIVACIAGMESVLDEFQFHRPLIACTLIGAVLGDMKTGIIIGGTLEMIA
LGWMNIGAAVAPDAALASIISTVLVIAGHQSIGAGIALAIPLAAAGQVLTIIVRTITVAF
QHAADKAAENGNLTALSWLHVSSLFLQAMRIAIPAVIVAISVGTSEVQGMLNAIPEVVTG
GLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGAVMAILYIQ
LSPKYNRVAGAPAAAAGNNDLDNELD