Protein Info for GFF2739 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Cardiolipin synthetase (EC 2.7.8.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR04265: cardiolipin synthase
  • amino acids 6 to 486 (481 residues), 733.2 bits, E=7.9e-225
• PF13396: PLDc_N
  • amino acids 19 to 59 (41 residues), 28.6 bits, 1.7e-10
• PF13091: PLDc_2
  • amino acids 134 to 243 (110 residues), 41.2 bits, E=2.1e-14
  • amino acids 332 to 446 (115 residues), 93 bits, E=2e-30
• PF00614: PLDc
  • amino acids 219 to 246 (28 residues), 32.9 bits, see alignment (E = 7e-12)
  • amino acids 400 to 426 (27 residues), 28.6 bits, see alignment (E = 1.6e-10)

Best Hits

Swiss-Prot: 100% identical to CLSA_SALPC: Cardiolipin synthase A (clsA) from Salmonella paratyphi C (strain RKS4594)

KEGG orthology group: K06131, cardiolipin synthase [EC: 2.7.8.-] (inferred from 100% identity to ses:SARI_01214)

MetaCyc: 94% identical to cardiolipin synthase A (Escherichia coli K-12 substr. MG1655)
CARDIOLIPSYN-RXN [EC: 2.7.8.41]

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (12/12 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (11/13 steps found)
• cardiolipin biosynthesis I (3/3 steps found)
• cardiolipin biosynthesis II (3/3 steps found)
• cardiolipin biosynthesis III (3/3 steps found)
• cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)

KEGG Metabolic Maps

• Aminophosphonate metabolism
• Glycerophospholipid metabolism
• High-mannose type N-glycan biosynthesis
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.- or 2.7.8.41

Protein Sequence (486 amino acids)

>GFF2739 Cardiolipin synthetase (EC 2.7.8.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGE
LHLGKRRAERARAMWPSTAKWLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQ
LQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLD
SAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSM
NMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPF
EQASGHTIHTIASGPGFPEDLIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQR
GVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTV
NLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFY
FFSPLL