Protein Info for GFF2731 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Two-component system response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 161 PF00072: Response_reg" amino acids 8 to 130 (123 residues), 70.7 bits, see alignment E=5.8e-24

Best Hits

Swiss-Prot: 44% identical to FILR2_METH6: Probable methanogenesis regulatory protein FilR2 (filR2) from Methanosaeta harundinacea (strain 6Ac)

KEGG orthology group: K02485, two-component system, unclassified family, response regulator (inferred from 54% identity to pen:PSEEN3402)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (161 amino acids)

>GFF2731 Two-component system response regulator (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSKNADAILLVEDNPDDAELTKLALARHGLDGRVTHVSDGMQALDYLHRRNGFTNRSGSN
PMLVLLDLKMPLLDGIGVLREIKGSDNLHHIPVVVLTSSTEPSDLLRAYDAGTNAYIAKP
TEFSQFLSAMKHVCEFWININQTAPQLPNAGVRTTGFGDLI