Protein Info for GFF2720 in Sphingobium sp. HT1-2

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1023 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 337 to 353 (17 residues), see Phobius details amino acids 360 to 379 (20 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 431 to 452 (22 residues), see Phobius details amino acids 465 to 490 (26 residues), see Phobius details amino acids 525 to 544 (20 residues), see Phobius details amino acids 858 to 878 (21 residues), see Phobius details amino acids 885 to 905 (21 residues), see Phobius details amino acids 915 to 935 (21 residues), see Phobius details amino acids 957 to 977 (21 residues), see Phobius details amino acids 988 to 1011 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1012 (1012 residues), 985.9 bits, see alignment E=1.1e-300 PF00873: ACR_tran" amino acids 8 to 1012 (1005 residues), 955 bits, see alignment E=4.5e-291 PF03176: MMPL" amino acids 850 to 1015 (166 residues), 31.6 bits, see alignment E=8.4e-12

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 64% identity to hdn:Hden_2823)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1023 amino acids)

>GFF2720 CzcABC family efflux RND transporter, transmembrane protein (Sphingobium sp. HT1-2)
MLKSLAAWALSYRLIVIALALLTAVLGAWAFVNLPVDAYPNIAQTQVKVILKAPGMTPEE
VESRVITPIEMEMLGIPGQAILRSSAKYAIADITIDFVDGTDIYWARQQVAERLSGVMGD
LPPAVSGGMAPISTPLSDIFMFTIEGPLSLEEKRTLLDWTIRPALRTVPGVADVNALGGY
VRTFEVRPDPIALASAGLGIADLQEAIERGNRNDGAGRLSQGEESLIVRAVGAIQSEADL
QSMVIATRNGRIVRMGDVATVGTGSLTRYGAVTANGKGEAVQGLVIALRGADARAVVDGV
KARVAELEKTLPQGTTIAVFYDRSDLIGRAVGTVEKALIEATILVIILLILFLGDWRAAA
IVAATLPMSALVTFLMMRGMGLSANLMSLGGLAIAIGMLVDGAVVVVENIVERLNHAKDD
GPPRLHNVYRATGEVVVPVSAGIVIIALVFLPLLSLEGLEGKLFAPVALTIIFALAGSLL
IALTLVPVLASLGLKAGHHGEPWIMRKLTPRYRALLDGAFGRKRLVYGLAALGLVLAGLA
YGAVGKTFMPSMDEGSVIVQTAKLPTINLDQSVLGDTAVQQSLMKDVPEIAQIIARVGTD
EIGLDPMSPNETDSFVVLKPQKEWRGDKAFVVDEIRKSLDKLPGIEPTFTQPIEMRVSEM
LTGSRGDLAVKIFGPDLATLSNLAGQVQKILSKTRGASEVMTVANDHVDYLQLDIDRAAA
GRFGMPIDQMQDTLRAQIEGVHAGVVADGQKRVPILVKGDETIRSDATRFADLPLRTPDG
TVARVSDMARVERTEGPVKLDHENGSRYALVQAFVSGRDLVGYVDEARATVDREIKMPAG
YRMVWGGQFENQQRASARLMLVIPAALLLILLVLLMTLRSMRASLLILANIPFAMVGGII
SLWVSGQYLSVPASVGFIALLGIAVLNGLVLVAYFRQLREEGQSMAQAVRLGAERRLRPV
LMTASITAFGLVPLMFAAGPGSEIQKPLAIVVIGGLISSTLLTLILLPILFERFGEGATE
ARS