Protein Info for GFF2716 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Possible protease sohB (EC 3.4.21.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 348 transmembrane" amino acids 7 to 30 (24 residues), see Phobius details amino acids 189 to 207 (19 residues), see Phobius details PF08496: Peptidase_S49_N" amino acids 2 to 157 (156 residues), 194.6 bits, see alignment E=1.5e-61 PF01343: Peptidase_S49" amino acids 160 to 309 (150 residues), 165.5 bits, see alignment E=1.4e-52

Best Hits

Swiss-Prot: 86% identical to SOHB_SHIFL: Probable protease SohB (sohB) from Shigella flexneri

KEGG orthology group: K04774, serine protease SohB [EC: 3.4.21.-] (inferred from 99% identity to sek:SSPA1079)

Predicted SEED Role

"Possible protease sohB (EC 3.4.21.-)" (EC 3.4.21.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (348 amino acids)

>GFF2716 Possible protease sohB (EC 3.4.21.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
VELLSEYGLFLAKIVTVVVAIAVIVLLIVNATQRKRQRGELRVTNLSEQYQEMKDDLAAA
LMDGHQQKLWHKAQKKKHKQEAKAAKAKAKLGDIATSDKPRVWVIDFKGSMDAHEVNALR
EEVTAVLAVAKPGDRAVVRLESPGGVVHGYGLAASQLQRLRDKNIPLTVTVDKVAASGGY
MMACVAEKIIAAPFAIVGSIGVVAQIPNFNRFLKSKDIDIELHTAGQYKRTLTLLGENTE
EGRQKFREDLNETHHLFKEFVQRMRPALDIEQVATGEHWYGQQALEKGLVDEINTSDEVI
LGLMEGREVLNVRYMQRKKLIDRVTGSAAESADRLLLRWWQRGQKPLM