Protein Info for GFF2707 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Phosphatidylglycerophosphatase B (EC 3.1.3.27)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 83% identical to PGPB_ECOLI: Phosphatidylglycerophosphatase B (pgpB) from Escherichia coli (strain K12)

KEGG orthology group: K01096, phosphatidylglycerophosphatase B [EC: 3.1.3.27] (inferred from 99% identity to sek:SSPA1085)

MetaCyc: 83% identical to phosphatidylglycerophosphatase B (Escherichia coli K-12 substr. MG1655)
RXN-11277 [EC: 3.6.1.75]; Undecaprenyl-diphosphatase. [EC: 3.6.1.75, 3.6.1.27]; Phosphatidylglycerophosphatase. [EC: 3.6.1.75, 3.6.1.27, 3.1.3.27]

Predicted SEED Role

"Phosphatidylglycerophosphatase B (EC 3.1.3.27)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 3.1.3.27)

MetaCyc Pathways

superpathway of phospholipid biosynthesis III (E. coli) (12/12 steps found)
phosphatidylglycerol biosynthesis I (6/6 steps found)
phosphatidylglycerol biosynthesis II (6/6 steps found)
superpathway of cardiolipin biosynthesis (bacteria) (11/13 steps found)
polyisoprenoid biosynthesis (E. coli) (5/5 steps found)
cardiolipin biosynthesis I (3/3 steps found)
cardiolipin biosynthesis II (3/3 steps found)
cardiolipin biosynthesis III (3/3 steps found)
di-trans,poly-cis-undecaprenyl phosphate biosynthesis (2/2 steps found)
phosphatidate metabolism, as a signaling molecule (2/5 steps found)
type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)
superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.27, 3.6.1.27

Use Curated BLAST to search for 3.1.3.27 or 3.6.1.27 or 3.6.1.75

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (254 amino acids)

>GFF2707 Phosphatidylglycerophosphatase B (EC 3.1.3.27) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLSIARRTAAGAALLLIMPLAVWVSGWQWQPGHQVWWLKTLFWITETVTKPWGVITHVIL
CGWFLWCLRFRLRAAIMLFAILGGAIIVGQGVKSWVKERVQEPRPFVVWLEKTHHIPVDE
FYTLKRTERGHLVKEQLAGQQNIPVFLRQHWQKETGFAFPSGHTMFAASWALLAVGLLWP
RRRTFTIAFLLVWATGVMGSRLLLGMHWPRDLVVATLISWLLVTLATWLAQRICGPLMPP
REEAQEIAEREQES