Protein Info for GFF2685 in Variovorax sp. SCN45

Annotation: DNA internalization-related competence protein ComEC/Rec2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 822 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 36 to 54 (19 residues), see Phobius details amino acids 65 to 86 (22 residues), see Phobius details amino acids 285 to 308 (24 residues), see Phobius details amino acids 322 to 343 (22 residues), see Phobius details amino acids 369 to 388 (20 residues), see Phobius details amino acids 392 to 410 (19 residues), see Phobius details amino acids 430 to 453 (24 residues), see Phobius details amino acids 457 to 479 (23 residues), see Phobius details amino acids 484 to 505 (22 residues), see Phobius details amino acids 511 to 531 (21 residues), see Phobius details PF13567: DUF4131" amino acids 37 to 219 (183 residues), 93.1 bits, see alignment E=2.4e-30 TIGR00361: DNA internalization-related competence protein ComEC/Rec2" amino acids 176 to 786 (611 residues), 355.1 bits, see alignment E=6.3e-110 PF03772: Competence" amino acids 263 to 529 (267 residues), 196.1 bits, see alignment E=1.2e-61 TIGR00360: ComEC/Rec2-related protein" amino acids 284 to 468 (185 residues), 86.9 bits, see alignment E=1.9e-28 PF00753: Lactamase_B" amino acids 564 to 756 (193 residues), 38.6 bits, see alignment E=1.7e-13

Best Hits

KEGG orthology group: K02238, competence protein ComEC (inferred from 80% identity to vpe:Varpa_2213)

Predicted SEED Role

"DNA internalization-related competence protein ComEC/Rec2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (822 amino acids)

>GFF2685 DNA internalization-related competence protein ComEC/Rec2 (Variovorax sp. SCN45)
VTRFRASGRAAGGSLGFVALAGSLLGAALQLQQPALWPAWVYAALLLVAIAWLWRWPSFF
DRRLWAMTLALLCGAMAGAGLAGWRAVVHAGGALAPAVEGRDLVVTGVVAEMPQRNEAGT
RFRLDVESARWADASVAEPLAVPDRIALGWYAENTGLWGRSSGGKAASANPVGPLHAGER
WRLAVRLKAPHGNVNPFGFDGELWAWEQGIQANGYVRAGTRDAVPERIAVTWLHPVERAR
EAVRDAIFERVPDRARAGVIAALVTGDQQAIDRAGWDVFRATGVAHLMSISGLHVTMFAW
LASRVVGWLWRRSPRLMLGLPAQQAALVGGVLLAGLYALFSGWGVPSQRTVWMLATVAVL
RLTGRRWPWPHVWLLTAAVVVALDPWALMQAGFWLSFVAVGVLFATDASVPGEPRAGASS
RLLGFFREQWVITLALAPLSLLLFQQVSLVGLLANAVAIPWVTLVVTPLAMLGVAFAPLW
DAAAWAVHVLSVLLQWCAGLPLATLSMATPPWWMAACGVGGGALLAMRLPWSLRAVGVPF
LLPVLLWQAPRPATGEFELLAADIGQGNAVLVRTATHSLLYDTGPRYSLESDAGHRVLVP
LLRAYGERLDMLVLSHRDTDHTGGAQAVLAMQAQAELLSSIEASHALQALRPAKRCEAGQ
RWHWDGVDFEVLHPEADDYPAFTAKPNAVSCVLRIGNGRAAALLAGDVERLQEAALIART
PRLRADVLLVPHHGSKTSSSETFLDAVQPRIALVQAGYRNRFGHPAPEVSARYAAHGVRL
VDSPRCGAAHWRSTQPAEVACERERHARYWRHRLPERAEIVN