Protein Info for GFF2658 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Na(+) H(+) antiporter subunit A; Na(+) H(+) antiporter subunit B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 982 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 78 to 99 (22 residues), see Phobius details amino acids 110 to 129 (20 residues), see Phobius details amino acids 134 to 152 (19 residues), see Phobius details amino acids 164 to 187 (24 residues), see Phobius details amino acids 207 to 228 (22 residues), see Phobius details amino acids 244 to 266 (23 residues), see Phobius details amino acids 272 to 293 (22 residues), see Phobius details amino acids 300 to 318 (19 residues), see Phobius details amino acids 324 to 348 (25 residues), see Phobius details amino acids 368 to 388 (21 residues), see Phobius details amino acids 408 to 429 (22 residues), see Phobius details amino acids 462 to 482 (21 residues), see Phobius details amino acids 507 to 526 (20 residues), see Phobius details amino acids 577 to 596 (20 residues), see Phobius details amino acids 608 to 631 (24 residues), see Phobius details amino acids 638 to 658 (21 residues), see Phobius details amino acids 664 to 685 (22 residues), see Phobius details amino acids 712 to 730 (19 residues), see Phobius details amino acids 768 to 786 (19 residues), see Phobius details amino acids 827 to 850 (24 residues), see Phobius details amino acids 859 to 881 (23 residues), see Phobius details amino acids 894 to 916 (23 residues), see Phobius details amino acids 936 to 958 (23 residues), see Phobius details PF00662: Proton_antipo_N" amino acids 66 to 112 (47 residues), 37.5 bits, see alignment 4.5e-13 PF00361: Proton_antipo_M" amino acids 128 to 404 (277 residues), 218.1 bits, see alignment E=3.9e-68 PF13244: MbhD" amino acids 624 to 687 (64 residues), 62.3 bits, see alignment 9.7e-21 PF20501: MbhE" amino acids 707 to 803 (97 residues), 152.5 bits, see alignment E=7e-49 PF04039: MnhB" amino acids 830 to 952 (123 residues), 120.7 bits, see alignment E=1.2e-38

Best Hits

KEGG orthology group: K05559, multicomponent K+:H+ antiporter subunit A (inferred from 71% identity to aaa:Acav_1966)

Predicted SEED Role

"Na(+) H(+) antiporter subunit A; Na(+) H(+) antiporter subunit B"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (982 amino acids)

>GFF2658 Na(+) H(+) antiporter subunit A; Na(+) H(+) antiporter subunit B (Hydrogenophaga sp. GW460-11-11-14-LB1)
MHVSLIFLVALPFVGSLLAALLPANARNTESTLAGAIALFCAVQAAMYFPEVAAGGVIRQ
EFVWLPSLGLNFVLRMDGFAWMFSMLVLGIGSLVVLYARYYMSPDDPVPRFFSFLLAFMG
AMSGVVLSGNLIQLVLFWELTSLFSFLLIGYWHHRRDARRGARMALTVTGAGGLCLLAGV
LVLGHIVGSYDLDVVLRAGDVVRAHPLYSTALILILLGAFTKSAQFPFQFWLPHAMAAPT
PVSAYLHSATMVKAGVFLLARLWPVLAGTDEWFWIVTCSGLITLLIGGFAAIFQKDLKGL
LAYSTISHLGLITTLLGMNSPLAAVAAVFHIINHATFKASLFMAVGIIDHEAGTRDIRRL
SGLARYMPVTATLTVVAGAAMAGVPLLNGFISKEMFFTEAVFVSAAPWFQRVLPVAAVVA
GMFSVAYSLRFTARVFFGPDTCANLPRVPHEPPHWMRVPIEVLVLACLVVGIVPQWSIQY
ILGTAALPVVGGELPEFDLAVWHGFNLPLWMSFLALAGGIVLYLLLRKPLQSGRIERAPL
VGLFNGKRLFHHAMARLTAAARSALRLLGTRRLQPQLFLLVLVTVVGSVAAFRLAVPNPS
LAPGDRTLLPFSPMFALLWVVGVGAAIGAVWQAKYHRLTALALMSVSGLTTVITFAWFSA
PDLALTQLSVEAVTTVLILLGLRWLPKRLEVQDDSEPLWERTKAKARRSRDLLLALAAGG
GMTALSYALMTRDFPQSISPFFLERALPEGGGTNVVNVMLVDFRGFDTLGEITVLGIVAL
TVYALLRRFRPAPESAELTAQQRALPADLDTDLVNPQLAEDTAQGYLMVPAVLVRLLLPI
ASVIAVYLFMRGHNEPGGGFVAGLVLSTAFILQYIVSGTQWVEANMQLMPQRWIAAGLLT
ATATGLGSFWFGYPFLTTHTAHLHLPLLGEIHVASALFYDIGVFTLVVGATLLILTALGH
QSVRGHRQAKVVEQETQPEGTP