Protein Info for GFF2646 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Kup system potassium uptake protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 45 to 68 (24 residues), see Phobius details amino acids 102 to 126 (25 residues), see Phobius details amino acids 139 to 157 (19 residues), see Phobius details amino acids 168 to 189 (22 residues), see Phobius details amino acids 210 to 233 (24 residues), see Phobius details amino acids 245 to 265 (21 residues), see Phobius details amino acids 285 to 309 (25 residues), see Phobius details amino acids 337 to 357 (21 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details amino acids 393 to 413 (21 residues), see Phobius details amino acids 419 to 440 (22 residues), see Phobius details PF02705: K_trans" amino acids 11 to 463 (453 residues), 628.3 bits, see alignment E=6.3e-193 PF22776: K_trans_C" amino acids 475 to 622 (148 residues), 141.1 bits, see alignment E=2.5e-45

Best Hits

Swiss-Prot: 82% identical to KUP_ACIAC: Probable potassium transport system protein kup (kup) from Acidovorax citrulli (strain AAC00-1)

KEGG orthology group: K03549, KUP system potassium uptake protein (inferred from 82% identity to aav:Aave_4541)

MetaCyc: 47% identical to K+:H+ symporter Kup (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Kup system potassium uptake protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (622 amino acids)

>GFF2646 Kup system potassium uptake protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
VSASKSSLAALTLGAIGVVYGDIGTSVLYAVKEVFGSGHVPFTHANVYGILSILFWTLTV
IVSLKYVVLVLRADNNGEGGLIAMLALASTAVKERPALRQTLLAIGIFGTALFYGDGVIT
PAISVLSAVEGLEVISPHFKHYVVPITLLVLFVLFAVQKRGTSGIGRFFGPITLAWFLTI
AALGVSKIVGHPEILGALNPLHALRFMWAQPGTAFIILGAVVLCVTGAEALYADLGHFGK
RPIRLAWFSVVMPCLTLNYFGQGALLLEDPAAVKNPFFNMAPEWLLLPLVIMATMATVIA
SQALITGAFSVTKQAIQLGYLPRLKVQHTSVKHTGQIYMPFVNWSLFTAIVLAVVMFKSS
SNLAAAYGIAVTLDMLITTVLTFYVVRYSWKYPLWLCALATGFFFLVDLAFFSSNLLKLF
AGGWFPLLIGGAVFTLMMTWKRGRSLMAEKQHAESIELGSFLDALFIAPPARVEGTAVFL
TADIGTVPNAMLHNLKHNKVLHEQNLFVTVRSHEVPWIGLDKRLQIEPLGHDCWQVVVNY
GFKNDQDLPEALSTMRGRGCDMGPMTTSYFLSRDVVVPTIGSGMAPWREKLFAQMHHNAS
AAAEFLNLPSNAVIELGSKVEI