Protein Info for GFF2635 in Methylophilus sp. DMC18

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 645 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF23500: DUF7133" amino acids 31 to 367 (337 residues), 41.7 bits, see alignment E=1.9e-14 PF07995: GSDH" amino acids 133 to 368 (236 residues), 57.7 bits, see alignment E=2.5e-19 PF08450: SGL" amino acids 448 to 602 (155 residues), 43.2 bits, see alignment E=7.4e-15

Best Hits

KEGG orthology group: None (inferred from 71% identity to mfa:Mfla_0535)

Predicted SEED Role

"L-sorbosone dehydrogenase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (645 amino acids)

>GFF2635 hypothetical protein (Methylophilus sp. DMC18)
MKKRLITCLLGAVLATVANASWADINDVRANLNKLHLPDGFQIDVYAEVPGARQMALGTN
GNVYVGTRGSHVYAVVDKNKDHKADQVVSILDDLKVGNGVAMVDGHLYVAEQHRITRYAA
PDFDLTLPFKAMREVVYEQLPDKAHHGWRYLAVGPNNKLYVTIGAPCNICDPTGHEASII
RMNADGSQVETFAKGVRNSVGMDFQPGTQTLFFTDNGVDLLGPDIPHDELNAAPKAGLHF
GFPYFAGGDTRDPNWKNKTPPAEVTKPVAEFQAHSANLGFKFYTGKQFPAEYQGNAIIAQ
HGSWNRKVPVGYQLVRVTFDAQHQVKETKPFIDGWLTADGEVWGRPTDVLQLADGSLLVS
DDYNGVLYRVSYTGKAGASGVNANTANTLSGFAMPESVFASPDGTLYVSEIGEFGKAGDG
KITRIAADGTRTTLAEGLNDPKGLDLFNGQLYVADNDRVVRIDTSNGKQTVVAAPSAFPQ
KPVFLNDIEIDGLGNVYVSDSGDDNGKGAGIFKLTPEGKVTQVLKANAGIKRPNGLLMDG
PNRLLVADFGTGKLFSVQLGGSKPAVTLLNQGFGGADGLIRDAYGMLYVSDWAGGNVWQL
SDPKATPQRIIQGYQSAADISLSADGKSLLIPDMKAGLLYRMPIH