Protein Info for GFF2629 in Hydrogenophaga sp. GW460-11-11-14-LB1
Annotation: Probable VANILLIN dehydrogenase oxidoreductase protein (EC 1.-.-.-)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to VDH_PSEFL: Vanillin dehydrogenase (vdh) from Pseudomonas fluorescens
KEGG orthology group: None (inferred from 75% identity to pna:Pnap_1022)MetaCyc: 62% identical to vanillin dehydrogenase monomer (Sphingomonas sp. SYK6)
Vanillin dehydrogenase. [EC: 1.2.1.67]; 1.2.1.67 [EC: 1.2.1.67]; 1.2.1.67 [EC: 1.2.1.67]
Predicted SEED Role
"Probable VANILLIN dehydrogenase oxidoreductase protein (EC 1.-.-.-)" in subsystem Phenylpropanoid compound degradation (EC 1.-.-.-)
MetaCyc Pathways
- superpathway of vanillin and vanillate degradation (9/10 steps found)
- vanillin and vanillate degradation II (2/2 steps found)
- 4-coumarate degradation (aerobic) (4/5 steps found)
- 4-coumarate degradation (anaerobic) (4/6 steps found)
- vanillin and vanillate degradation I (1/2 steps found)
- trans-caffeate degradation (aerobic) (1/4 steps found)
- pinoresinol degradation (2/10 steps found)
KEGG Metabolic Maps
- 2,4-Dichlorobenzoate degradation
- Alkaloid biosynthesis I
- Biosynthesis of phenylpropanoids
- Carotenoid biosynthesis - General
- Insect hormone biosynthesis
- Nucleotide sugars metabolism
- Porphyrin and chlorophyll metabolism
- Puromycin biosynthesis
- Trinitrotoluene degradation
- alpha-Linolenic acid metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.-.-.-
Use Curated BLAST to search for 1.-.-.- or 1.2.1.67
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (484 amino acids)
>GFF2629 Probable VANILLIN dehydrogenase oxidoreductase protein (EC 1.-.-.-) (Hydrogenophaga sp. GW460-11-11-14-LB1) MSDLSMLINGLKVTAEKGATFERRNPLDGSVATRAPAASPADAVMAVEAAAEAFKTWSET GPNERRALLLKAADALEAKLPQFIEAVAAETGATGMWAGFNTMLAASMIREAASLTTQVA GEVIPSDVPGSLAMGVRQAAGVVLGIAPWNAPIILGVRAICVPLACGNTVIFKGSENCPR THQLIVESFQDAGFPPGVVNYITNAPADAGAVVEAMVAHPAVRRVNFTGSTKVGKIIAMT CAKYLKPVVLELGGKAPMVILDDANIEDAVNGAAFGCFANSGQICMSTERLIVDQKIADE FVKKFSDKAKALPLGDPRKPEPVVLGSVIGQGTVDHCNALIDDAIAKGAKLLCGGKADST LMPATVLDHVTPAMRIYHEETFGPVKCVVRVNGVEEAIACANDNEYGLSSAVFGGDIARA FNVARKIDSGICHVNGPTVHDEAQMPFGGVKGSGIGRFGGKAGINEFTELRWITMQTTPR HYPF