Protein Info for GFF2628 in Xanthobacter sp. DMC5

Annotation: Gluconate 5-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 259 transmembrane" amino acids 226 to 250 (25 residues), see Phobius details PF00106: adh_short" amino acids 20 to 204 (185 residues), 166.4 bits, see alignment E=8.7e-53 PF08659: KR" amino acids 21 to 179 (159 residues), 39.8 bits, see alignment E=7.1e-14 PF13561: adh_short_C2" amino acids 24 to 256 (233 residues), 183.3 bits, see alignment E=9e-58

Best Hits

Swiss-Prot: 40% identical to DER_CHICK: D-erythrulose reductase (DER) from Gallus gallus

KEGG orthology group: None (inferred from 62% identity to ara:Arad_12307)

MetaCyc: 38% identical to D-gluconate 5-dehydrogenase monomer (Gluconobacter oxydans 621H)
1.1.1.-

Predicted SEED Role

"Short-chain dehydrogenase/reductase SDR"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (259 amino acids)

>GFF2628 Gluconate 5-dehydrogenase (Xanthobacter sp. DMC5)
MATAEFPTTTPSFRLDGRRALVSGAGRGLGAALSIALAEAGAEVTLASRTLAEVEAVAQF
IQGRGGRAQALCLNVTDCDAVADTIARLPFFDTLVNNAGTNRPEPFVTVSPGNFDAVFAL
NVRAPFFLSQAVSRRLLAEERPGSIIHISSQMGHVGGANRSVYCATKHAIEGLTNAMAQE
LGPHGIRVNSICPTFIETPMTGPFLADPEFRSFALRKIKLGRLGWLDDVMGAVVFLASDA
SALMTGAALMLDGGWTSTS