Protein Info for GFF2627 in Variovorax sp. SCN45

Annotation: Chorismate synthase (EC 4.2.3.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01264: Chorismate_synt
  • amino acids 10 to 344 (335 residues), 420.6 bits, E=1.7e-130
• TIGR00033: chorismate synthase
  • amino acids 10 to 348 (339 residues), 433.9 bits, E=2.1e-134

Best Hits

Swiss-Prot: 92% identical to AROC_VARPS: Chorismate synthase (aroC) from Variovorax paradoxus (strain S110)

KEGG orthology group: K01736, chorismate synthase [EC: 4.2.3.5] (inferred from 93% identity to vpe:Varpa_2266)

MetaCyc: 63% identical to chorismate synthase (Escherichia coli K-12 substr. MG1655)
Chorismate synthase. [EC: 4.2.3.5]

Predicted SEED Role

"Chorismate synthase (EC 4.2.3.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 4.2.3.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.5

Protein Sequence (369 amino acids)

>GFF2627 Chorismate synthase (EC 4.2.3.5) (Variovorax sp. SCN45)
MSGNTFGTLFAVTNFGESHGPAIGCVIDGCPPGMELSEADIQADLDRRRPGTSRHVTQRN
EPDAVQILSGVYEGKTTGTPIALLIQNTDQRSKDYGQIAQQFRPGHADFTYWKKYGIRDP
RGGGRSSARLTAPTVAAGAVAKKWLAEKYGMVFRGCMTQIGEIAIPFESWDHVPNNPFFA
PVADVSALEDYMDHLRKAGDSCGARIRVTATKVPVGLGEPLYDKLDAEIAYAMMGLNAVK
AVEIGAGFDSVVQRGTTHGDSITPTGFLSNNAGGILGGISSGQDLEVSIAIKPTSSIISP
RQSIDIHNNPVEVVTKGRHDPCVGIRATPIAESLLALVVMEHVLRNRAQCGDVEQQQQTE
ASSPKASFL