Protein Info for GFF2596 in Variovorax sp. SCN45

Annotation: Multidrug resistance transporter, Bcr/CflA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 406 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 46 to 65 (20 residues), see Phobius details amino acids 77 to 95 (19 residues), see Phobius details amino acids 106 to 123 (18 residues), see Phobius details amino acids 135 to 157 (23 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 215 to 241 (27 residues), see Phobius details amino acids 248 to 270 (23 residues), see Phobius details amino acids 283 to 304 (22 residues), see Phobius details amino acids 342 to 363 (22 residues), see Phobius details amino acids 373 to 394 (22 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 14 to 391 (378 residues), 201.4 bits, see alignment E=1.5e-63 PF07690: MFS_1" amino acids 29 to 355 (327 residues), 134 bits, see alignment E=3.1e-43

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 90% identity to vpe:Varpa_2297)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (406 amino acids)

>GFF2596 Multidrug resistance transporter, Bcr/CflA family (Variovorax sp. SCN45)
VSAPGARKGRFDISFALLLPLLLAAQPVATDSYLPALPAIAKELGSASTSLTLFVLAFGF
AQLLCGPLADRFGRRPVLLAGLGCYVLAALGGAFADSVALLAGWRALQGFSMAAILVCSR
AAVRDLYPAHEGPHVMARGLTGLGVVGLLAPLLGAWLVQGAGWRWVMVAMAVYASVLFAM
CWYSFAETRKPMGEDGLSAPRGSTRTVFASRSFRAWASVAASTYGGLFCFLLLSPMVYIG
YLGWSPAWYGWIPAGGSLVYIFSTTMCRTLLRRYGPVRTVRLGASLSITGAVIQALGCWL
MPLSAVPLLFGHAVYCLGHGIHQPCGQAGAVGDLPHLAGRAVSWSGFGMMMVAFCVGQLA
ARFVDADYSYGAWPMVVPMLLAGISLMAIAFFWLPRLQHPTKETTP