Protein Info for GFF2579 in Xanthobacter sp. DMC5

Annotation: Long-chain-fatty-acid--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 27 to 366 (340 residues), 284.5 bits, E=1.2e-88
• PF13193: AMP-binding_C
  • amino acids 416 to 491 (76 residues), 52.7 bits, E=7e-18

Best Hits

KEGG orthology group: None (inferred from 85% identity to xau:Xaut_0518)

Predicted SEED Role

"Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 6.2.1.16)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (49/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• palmitate biosynthesis III (21/29 steps found)
• 2-deoxy-D-ribose degradation II (4/8 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• stearate biosynthesis I (animals) (1/6 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

• Butanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.16

Protein Sequence (509 amino acids)

>GFF2579 Long-chain-fatty-acid--CoA ligase (Xanthobacter sp. DMC5)
MTKNHLFSAIRAAIPAMDKPLARLIDGTVETYGDALALSARLANLLVARGVKPGDRVAVQ
VEKSWPALALYLATIRAGAVYLPLNTAYTLNEVEYFLSDAEPAVFVCRPEIEQDARALAA
RLGVGAVETLGTDGKGSLTDAAAAFPDTFEDVARGAEDLGGILYTSGTTGRAKGAMLTHA
NLLSNAQTLKDYWRFTADDVLLHALPIFHTHGLFVASNIVLLAGASMEFRSKFDPKEAVA
LMSAGKVTTLMGVPTFYTRLLDQPGLTREATKGMRLFISGSAPLLAETHRAFEERTGHAI
LERYGMTETCMNTSNPYDGARIAGTVGYPLPGISVRVTDPETGAVLPTGEIGMIEVQGPN
VFKGYWRMPEKTAAEFRDGFFITGDLGKIDENGYVHIVGRGKDLVITGGFNVYPKEVEGE
IDAIPGVVESAVIGVPHPDFGEGVTAVIVAQKDATLTEEAVHRALENRLAKFKQPKRVFF
VSELPRNTMGKVQKNILRETYKDIYRNVA