Protein Info for GFF2572 in Xanthobacter sp. DMC5

Annotation: Efflux pump membrane transporter BepE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1069 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 344 to 363 (20 residues), see Phobius details amino acids 370 to 392 (23 residues), see Phobius details amino acids 399 to 421 (23 residues), see Phobius details amino acids 441 to 462 (22 residues), see Phobius details amino acids 472 to 491 (20 residues), see Phobius details amino acids 540 to 557 (18 residues), see Phobius details amino acids 876 to 893 (18 residues), see Phobius details amino acids 905 to 925 (21 residues), see Phobius details amino acids 931 to 953 (23 residues), see Phobius details amino acids 977 to 999 (23 residues), see Phobius details amino acids 1006 to 1032 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 2 to 1032 (1031 residues), 1034.6 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1046 (1044 residues), 1099 bits, see alignment E=0 PF03176: MMPL" amino acids 874 to 1038 (165 residues), 31.9 bits, see alignment E=7.3e-12

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 80% identity to azc:AZC_3305)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1069 amino acids)

>GFF2572 Efflux pump membrane transporter BepE (Xanthobacter sp. DMC5)
MISRFFIERPVLSNVLALVFVLIGLVSLIRLPVSQYPNIVPPTVSVSTSYPGASAKTMID
TVALPIEQQVNGVEGMIYMQSWSASDGTYTLVVSFAIGTDPNMAQVLVQNRVNIALASLP
TAVQAQGVTILQKGTSILEFVTLISPDGRYDGLFLNNYAIINIQNELERVDGVANVAVFG
AGTYAMRVWMDPDRMQAFGLTPTDVSNAIQKQSQIVTPGQLGLPPAPSNASFQYTVNVSG
RLDDVKDYENIIVKVDNSDGGRIVRIRDIGRVELGAQSYSKDFMQDNKPAAGIGIFQLPA
ANALDVAKRVAAKMEDLKKNFPEGLDYAIPFDTTLFVTASIDEVWKTLFEAAILVLVVIL
LFLQDWRATLVPATTVPVTIIGAFAAMDAMGFTINLSTLFAIILAIGIVVDDAIVIVEGV
ARHIEEGMAGQPAAEKAMDELFGPVVGITLVLMSVFLPASFIPGLSGQMFKQFALVIAAT
AFISAINAATLKPTQCALWLRQPVPPEKRNFIYRGFNAIYGKAEHWYTGVISRMVHHSKL
MVLIAIALMSVAGYGLTRIPTAFLPIEDQGYFLAHVQLPDASNLNRTKKVMADVSERIRK
VPGVQTVLAISGISVLDNSSTLANAGVTYITLTPWDVRYATKGQDLLSMYENLGKAVAGV
EEAEVVILVPPAIQGIGNAAGFTMQPQIRNGNFDYQLLEQITASMVDKGRAQSALSHVSS
SFRAGAPQIQVEVNRIKAETLGITVGQVFSTISAYLGSTYVNQINKFGNVFQVYIQADAG
FRVTPADLMQLKVRSPTQNAMIPLGTVVDIKMTLGPPLISLYNLYPSSTIVGTNAAGFSS
GQALSLMEQIAASTLPPGTGFEWTAMSYQEKAVGNQIYYVFGLAILLVYFVLAGQYESWI
QPMSVILAVPLALLGTVSALLGLGVANNLYTQIGLVLLIALASKNAILIVEYAREKRAEG
MEIMDAAVEASRLRFRPILMTSFAFILGVLPLVFATGAGANSRKSIGIAVVSGMLASTCL
AVLFVPSFYTVLQRFEEGRKGKKKSSAGHAPPEPPPAPDAGVPPAPASA