Protein Info for GFF2540 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Tyrosine-protein kinase EpsD (EC 2.7.10.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 795 transmembrane" amino acids 59 to 78 (20 residues), see Phobius details amino acids 482 to 501 (20 residues), see Phobius details PF02706: Wzz" amino acids 42 to 136 (95 residues), 56.5 bits, see alignment E=8.7e-19 PF13807: GNVR" amino acids 431 to 503 (73 residues), 52.9 bits, see alignment E=8.9e-18 TIGR01007: capsular exopolysaccharide family" amino acids 554 to 759 (206 residues), 150.7 bits, see alignment E=2e-48 PF10609: ParA" amino acids 575 to 628 (54 residues), 27.2 bits, see alignment 7.6e-10 PF01656: CbiA" amino acids 576 to 751 (176 residues), 35.4 bits, see alignment E=3e-12 PF13614: AAA_31" amino acids 583 to 698 (116 residues), 30.7 bits, see alignment E=8.8e-11

Best Hits

KEGG orthology group: K08252, receptor protein-tyrosine kinase [EC: 2.7.10.1] (inferred from 44% identity to ajs:Ajs_3012)

Predicted SEED Role

No annotation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.10.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (795 amino acids)

>GFF2540 Tyrosine-protein kinase EpsD (EC 2.7.10.2) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTTDQHHLPYVPDPRDAPSLYREAGPSERSRSRGETIALTEDRLDLRTIYRAMVRRKGTI
LGIAALCSLAAGAYTLSITPEYQSSAMLQIDRAAQKVVGFNTEVEVEEGPLSDQLQLRTQ
VELLKSRSLAERVIDEMGLHKPGGMSTAPEPLAPEAASAASSGLMDQAAAVGRQAWSQLH
ALIAPAPPAPDSLSRAATVAQFQQAVTVEPVRNSRLVQIGVRNADPALAAAIANTMAKTF
IAMHIERRLESSVYARQFLEEQIRQSKTKLEDSERVINEYAKKNQILNLGDKGSATTQTF
VDFSTALTHAQQERIKAETLYNQVRLNPESAPQAVVNEAIRAYKEQRARLEADYAKNRSV
FKPDYPAMVQARAQIAELDGRIKTEVNNILSSIQGQYMAAVKAEEQLKNKVAASRSEVLT
VQDRSVDMNLLSRELDTNRQVYDSLLQRLREVSVTAGITTNNISIVDQASVPRFPAAPNL
KVNIGLGVLLGLFLGMLAALLREQMDDSVKSVNDIEGQYRLPLLGLIPYTRSAGVRREPV
ALLAHREPRSTFAESYRSVRTVLQFGSAEGPPQRFMVTSCGTGEGKSTTALALAINFAQL
GQKVLLIDADMRKGGLHKMLKLSNERGLSTLLEADRAIAGSIQDTTVANLGVITAGPTPP
DPVELLMGPRLGTLLEQAQALGYTQIVIDGPPLLGLADAIVLGNQIPNIVLAVKAGGTRK
DSMKDGLRRLRTAGLSPMGVVLTHARNEHNNDHAYAAYYGHGAPPAPRPAPVRSPPPVAL
PPGTRIEPTLDPSTA