Protein Info for GFF2532 in Variovorax sp. SCN45

Annotation: Potassium efflux system KefA protein / Small-conductance mechanosensitive channel

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 821 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 223 to 242 (20 residues), see Phobius details amino acids 263 to 284 (22 residues), see Phobius details amino acids 304 to 322 (19 residues), see Phobius details amino acids 342 to 360 (19 residues), see Phobius details amino acids 370 to 393 (24 residues), see Phobius details amino acids 413 to 437 (25 residues), see Phobius details amino acids 448 to 471 (24 residues), see Phobius details amino acids 498 to 521 (24 residues), see Phobius details amino acids 545 to 567 (23 residues), see Phobius details amino acids 589 to 611 (23 residues), see Phobius details amino acids 617 to 642 (26 residues), see Phobius details PF12607: DUF3772" amino acids 145 to 204 (60 residues), 45 bits, see alignment 7.1e-16 PF00924: MS_channel_2nd" amino acids 634 to 699 (66 residues), 76 bits, see alignment E=2e-25

Best Hits

KEGG orthology group: None (inferred from 85% identity to vpe:Varpa_4810)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (821 amino acids)

>GFF2532 Potassium efflux system KefA protein / Small-conductance mechanosensitive channel (Variovorax sp. SCN45)
MKRTSRLASFCLATLLALSMCGLALAQPDASMNAGNGSNPNNSANTAVAAPPAPTVAELR
AQFNKITAATGSNADDDPRKQLAQISDIGAQADKFVAARTGDLADLNARLGELGNPPAAG
ATEDPDITRQRARLTKERNALDADIRLAKLLSIDVRQRGADLVSQRREMFEAQLTERAAS
PLTGEFWTDLQDAWPDDLERLQAMGSVVNDGFVQALAPASRTLVIAALIGALLLAWLGVW
GAEHLLARLATRVLPAGRLRRSLLVIAIVATHVLLVAVAAHGFVEVLKAHATWDAQARKA
LQSAAQALTFMAFVIGLGRALLATSRPSWRLPPIPDATASRLAALPWLVALVAALAWTPA
EINALIDASFAAVVATHVLTALILTALVGTVIYRFKALRADAPEAGLPERPMWVGLLVAL
IGALMIAIWVLVALGYVALGSFLASQLTWTGIVAAAFYVLFKFADDVFMAVVSSRSTFGQ
RLQKSFGLAPQTLDQAATVLSGISRVALFVYMLIALAAPLGTSPGEVFQRSGKLGTGVKV
GEFQLVPGAILSALTVAVVGFILLRVFKRWLTRSYLPNTQFEPGMQSSITTLLGYVGGIL
VVAFTLSALGIGIERIAWVASALSVGIGFGLQAIVQNFISGLILLAEQPVKVGDWVVLGT
AEGDVRRINVRATEIQLGDRSTLIVPNSEFITKTVRNMTLANAEGRVLIRLPMPLTTDAQ
RVRELILAACKAHEGVLETPAPSLTLEGIENGLLIFQAIAYVASPRLAGGVRSDLLFVIL
DELKKASLPLAVPTMVMAAAPEVPAPIVPSSPASPIPGVQS