Protein Info for PS417_12810 in Pseudomonas simiae WCS417

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 388 transmembrane" amino acids 43 to 62 (20 residues), see Phobius details amino acids 68 to 87 (20 residues), see Phobius details amino acids 108 to 127 (20 residues), see Phobius details amino acids 133 to 153 (21 residues), see Phobius details amino acids 158 to 177 (20 residues), see Phobius details amino acids 183 to 201 (19 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 227 to 387 (161 residues), 173.8 bits, see alignment E=1.2e-55 PF00990: GGDEF" amino acids 229 to 383 (155 residues), 159 bits, see alignment E=4.4e-51

Best Hits

KEGG orthology group: None (inferred from 91% identity to pfs:PFLU2764)

Predicted SEED Role

"FIG00955126: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U691 at UniProt or InterPro

Protein Sequence (388 amino acids)

>PS417_12810 diguanylate cyclase (Pseudomonas simiae WCS417)
MAPLSWQSDRANFMNGLERGQDHDCFIEEQVRTDRLHQLFRQSFAAIFGSYLAAVMLCWL
CWERFDHQVILVWLVVLAATSLIRIMMFMKWFRCPNAERTPDRWERRYWVTLLLSAATWG
LGALAVMPTDDRLSQVLVMLFTVGMSVSAVSCYSAYRYMTLASMAVVLLPCTLWLLFQPS
SMQVGVAVAVLVFSTFVVSATRKLSDALEKAFRLTRQMERAHNISTRAAQTDELTGLMNR
RAFFEHAQVLYAQCRHNRQPLCALMMDMDHFKEINDTYGHQAGDQVLRQIGGVISTSFRQ
ADVYGRLGGEEFAVLLPNTSLETARDIAEQLIKAISGLASEPVHGLTASLGVASTHAQDQ
DLHGLMNTADKALYRAKAQGRNQVAVAE