Protein Info for GFF2504 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Permease of the drug/metabolite transporter (DMT) superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details amino acids 34 to 53 (20 residues), see Phobius details amino acids 60 to 83 (24 residues), see Phobius details amino acids 89 to 109 (21 residues), see Phobius details amino acids 118 to 136 (19 residues), see Phobius details amino acids 142 to 162 (21 residues), see Phobius details amino acids 174 to 196 (23 residues), see Phobius details amino acids 215 to 236 (22 residues), see Phobius details amino acids 245 to 264 (20 residues), see Phobius details amino acids 271 to 290 (20 residues), see Phobius details PF00892: EamA" amino acids 8 to 131 (124 residues), 56.6 bits, see alignment E=1.7e-19 amino acids 144 to 287 (144 residues), 56.7 bits, see alignment E=1.6e-19

Best Hits

Swiss-Prot: 100% identical to EAMA_SALTY: Probable amino-acid metabolite efflux pump (eamA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03298, drug/metabolite transporter, DME family (inferred from 99% identity to spq:SPAB_01787)

MetaCyc: 84% identical to cysteine/O-acetylserine exporter EamA (Escherichia coli K-12 substr. MG1655)
RXN0-1923; RXN0-1924

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (300 amino acids)

>GFF2504 Permease of the drug/metabolite transporter (DMT) superfamily (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MMSRKDGFLALLVVVVWGLNFVVIKVGLHHMPPLLLAGLRFLLVAFPAIFFVARPKVPLT
LLLGYGLTISFGQFAFLFCAIKFGMPAGLASLVLQAQAFFTMALGAFVFSERLQRKQLAG
IALAIIGVLVLIEASLNGQHIAMSGFMLTLAAAFSWACGNIFNKKIMQHSPRPAVMSLVV
WSALIPILPFLLSSLLLEGADHITQSLITIDMTTILSLLYLAFVATILGYGIWGALLGRY
ETWRVAPLSLLVPVVGLASAAVLLGETLTGMQLAGAVLIMAGLYINVFGFRVRRTARVSG