Protein Info for PS417_12750 in Pseudomonas simiae WCS417

Annotation: acriflavine resistance protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 336 to 353 (18 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 431 to 456 (26 residues), see Phobius details amino acids 465 to 487 (23 residues), see Phobius details amino acids 529 to 548 (20 residues), see Phobius details amino acids 857 to 875 (19 residues), see Phobius details amino acids 882 to 902 (21 residues), see Phobius details amino acids 908 to 932 (25 residues), see Phobius details amino acids 954 to 974 (21 residues), see Phobius details amino acids 987 to 1012 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 7 to 1012 (1006 residues), 1067.1 bits, see alignment E=0 PF03176: MMPL" amino acids 328 to 504 (177 residues), 21.1 bits, see alignment E=1.4e-08

Best Hits

Swiss-Prot: 57% identical to MDTC_ECOUT: Multidrug resistance protein MdtC (mdtC) from Escherichia coli (strain UTI89 / UPEC)

KEGG orthology group: K07789, RND superfamily, multidrug transport protein MdtC (inferred from 69% identity to avn:Avin_28790)

MetaCyc: 57% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Acriflavin resistance plasma membrane protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U992 at UniProt or InterPro

Protein Sequence (1035 amino acids)

>PS417_12750 acriflavine resistance protein B (Pseudomonas simiae WCS417)
MNLSGPFIRRPVATMLLSLAIMLLGGVSFNLLPVSPLPQIDFPVIVVSASLPGASPEVMA
STVATPLERSFGSIAGITTMSSSSSQGSTRVILAFDSDRDINGAAREVQAAINASRNLLP
SGMRSMPTYKKINPSQAPIMVLSLTSDVLQKGQLYDLASTILSQSLSQVPGVGEVQIGGS
SLPAVRIELEPKALDQYGVALDDVRNTIANANQRRPKGSLEDSQRNWQIQANDQLEKAKD
YEPLLIRYQNGAALRLGDVAKISDGVEDRYNSGFFNNEPAVLLVINRQSGANIIETVRQI
KAQLPALQAVLPSSVKLSLAMDRSPVITATLHEAEMTLLIAVGLVILVVYLFLGNFRASL
IPTLAVPVSLVGTFAVMYLYGFSLNNFSLMALILATGLVVDDAIVVLENISRHIDEGVPP
MKAAYLGAQEVGFTLLSMNVSLVAVFLSILFMGGIVTNLFREFSITLSAAIIVSLIVSLT
LTPMLCARWLKPHVKGQMTGLQRWSQKINDRMVAGYATSLDWVLRHRRLTLLSLLLTIGL
NVALYVVVPKTFMPQQDTGQLIGFVRGDDGLSFSVMQPKMETFRKAVLKDPAVLSVAGFI
GGNNGTNNAVMLVRLKPISERKISAQAVIERLRKDVPLVPGGRLFLMADQDLQFGGSRDQ
TSAQYSYILQSGDLAALRLWYPKVVAALRELPELTAIDAREGRGAAQVTLIVDRDQAKRL
GIDMDMVTSVLNNAYSQRQISTIYDSLNQYQVVMEVNPRYAQDPITLNQMQVITADGARV
PLSTIAHYENSLADDRVSHEGQFASENIAFDMAPGVTVEQGTAAIERAIAKVGLPEDVIA
KMAGTADAFAATQKGQPFMILGALVAVYLVLGILYESYIHPLTILSTLPSAGVGAMLAIY
LTGGEFSLISLLGLFLLIGVVKKNAILMIDLALQLERHDGMSPLESIRSACLLRLRPILM
TTLAAILGALPLLLGAGDGAEMRRPLGLTIIGGLVFSQILTLYTTPVVYLYLDRARHRFN
AWRGVRTDAALDTAL