Protein Info for GFF2485 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Xaa-Pro aminopeptidase (EC 3.4.11.9)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 PF05195: AMP_N" amino acids 13 to 129 (117 residues), 126 bits, see alignment E=6.8e-41 PF00557: Peptidase_M24" amino acids 184 to 445 (262 residues), 203.5 bits, see alignment E=3.4e-64

Best Hits

KEGG orthology group: K01262, Xaa-Pro aminopeptidase [EC: 3.4.11.9] (inferred from 80% identity to vpe:Varpa_5977)

Predicted SEED Role

"Xaa-Pro aminopeptidase (EC 3.4.11.9)" (EC 3.4.11.9)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>GFF2485 Xaa-Pro aminopeptidase (EC 3.4.11.9) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MARMDSTTHTTLYAERRARVAAQLGAGGIAIVPTALERPRNRDTDFIYRHDSYFYYLTGF
TEPNAWLVITAEGQTTLFCQPKDLEREIWDGIRLGPEAAPAHLGVSEAFSVAELDQRLPK
LLENRHTVWYPFATHAGLESRINGWLQPVRARVRYGALCPESQRDLCGILDELRLVKDAF
EQATMRRAAQISAKAHIRAMQRSAAMLRAGQDVREYHLDAELLHSFREHGSQYPAYGSIV
AAGANACVLHYRADAAPIRSGELVLIDAGCELDGYASDITRTFPANGRFTGPQRTLYDLV
LASQDAAVAATKAGARFVDPHEATVAVLAQGLLDVGLLDRNKVGNAQDVIAHRAYFPFYM
HRTGHWLGMDVHDCGSYVEPSELGNVSERQDPLSGETIKDRPSRVLRPGMVLTIEPGLYV
RPGEGVPEHFWNIGIRIEDDAIVTATGCELISRDVPVKADEIEALMRA