Protein Info for GFF245 in Xanthobacter sp. DMC5

Annotation: Delta(1)-pyrroline-2-carboxylate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02423: OCD_Mu_crystall
  • amino acids 7 to 309 (303 residues), 207.3 bits, E=2.8e-65
• PF01488: Shikimate_DH
  • amino acids 116 to 212 (97 residues), 44.1 bits, E=2.2e-15

Best Hits

Swiss-Prot: 44% identical to YK01_SCHPO: Uncharacterized protein P11E10.01 (SPAP11E10.01) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)

KEGG orthology group: K01750, ornithine cyclodeaminase [EC: 4.3.1.12] (inferred from 72% identity to xau:Xaut_3506)

Predicted SEED Role

"Ornithine cyclodeaminase (EC 4.3.1.12)" in subsystem Arginine and Ornithine Degradation (EC 4.3.1.12)

MetaCyc Pathways

• L-ornithine degradation I (L-proline biosynthesis) (1/1 steps found)
• L-arginine degradation VII (arginase 3 pathway) (1/2 steps found)
• L-proline biosynthesis II (from arginine) (1/2 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.1.12

Protein Sequence (311 amino acids)

>GFF245 Delta(1)-pyrroline-2-carboxylate reductase (Xanthobacter sp. DMC5)
MVAFYDAGEVEAALTYERLVPALQAAFAAAQVESPVRGVHHVGNEETPGRLLTMPAWRPG
QVFGVKLVNVFPTNGARGLGAVHGVYALFDGSTGIPTAIIEADALTNRRTAATSALASTF
LSRMDSETLTLVGTGNLAFQLAQGHCAVRPIRRVLVWGRSSERAAAMAANLAALGLPAEP
VSDLSAAVAAADIVTSATTSNDPLVLGQDVKPGTHVDLVGAFTPTMRESDDALIRASDVY
VDTYAGALGEAGDLLLPVAAGVWSTDQVKADLYELCGGTKEGRTDPKAITLFKSVGASIE
DLVAAELVAGR