Protein Info for GFF2443 in Variovorax sp. SCN45

Annotation: Iron-sulfur cluster regulator IscR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 180 TIGR00738: Rrf2 family protein" amino acids 1 to 131 (131 residues), 116.5 bits, see alignment E=3.9e-38 PF02082: Rrf2" amino acids 3 to 133 (131 residues), 111.9 bits, see alignment E=1.2e-36

Best Hits

Swiss-Prot: 50% identical to ISCR_XENNA: HTH-type transcriptional regulator IscR (iscR) from Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)

KEGG orthology group: None (inferred from 83% identity to vpe:Varpa_4878)

Predicted SEED Role

"Iron-sulfur cluster regulator IscR" in subsystem Rrf2 family transcriptional regulators

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (180 amino acids)

>GFF2443 Iron-sulfur cluster regulator IscR (Variovorax sp. SCN45)
MRLTTKGRFAVTAMIDIALHGRSGPVTLASISMRQRVSLSYLELLFGKLRRNDLVESTRG
PGGGYSLSRKAADISVADIVLSIEEHDAESTRQRGADVPGEPGRCEIDELWATVNLRAVE
FLKSISLQSLVDEQKAKGVQAAARTDSRRTPAGQPATRKPFVVDAPNSVFALGRRQQSAS