Protein Info for GFF2440 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Adenine phosphoribosyltransferase (EC 2.4.2.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01090: adenine phosphoribosyltransferase
  • amino acids 7 to 177 (171 residues), 220.5 bits, E=7.2e-70
• PF00156: Pribosyltran
  • amino acids 30 to 158 (129 residues), 57.2 bits, E=6.3e-20

Best Hits

Swiss-Prot: 85% identical to APT_RHOFT: Adenine phosphoribosyltransferase (apt) from Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)

KEGG orthology group: K00759, adenine phosphoribosyltransferase [EC: 2.4.2.7] (inferred from 85% identity to rfr:Rfer_4239)

MetaCyc: 54% identical to adenine phosphoribosyltransferase (Sinorhizobium meliloti 1021)
Adenine phosphoribosyltransferase. [EC: 2.4.2.7]

Predicted SEED Role

"Adenine phosphoribosyltransferase (EC 2.4.2.7)" in subsystem Purine conversions or cAMP signaling in bacteria (EC 2.4.2.7)

MetaCyc Pathways

• superpathway of purine nucleotide salvage (13/14 steps found)
• adenine and adenosine salvage I (2/2 steps found)
• adenine and adenosine salvage II (2/2 steps found)
• guanine and guanosine salvage II (2/2 steps found)
• guanine and guanosine salvage I (1/2 steps found)
• adenine salvage (1/3 steps found)
• superpathway of guanine and guanosine salvage (1/3 steps found)
• glyphosate degradation III (2/7 steps found)
• (aminomethyl)phosphonate degradation (2/8 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.7

Protein Sequence (181 amino acids)

>GFF2440 Adenine phosphoribosyltransferase (EC 2.4.2.7) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MDTSAFLKSHIRTVPDWPAPGVQFRDITPLLQDPKVFRVLIDTFVHRYMDAAMRPTVVAG
LDARGFIIGSVLAYELGVGFVPIRKKGKLPFTTVEETYELEYGSATVELHTDAVKAGDRV
VLIDDLIATGGTMMAGRRLLEKLGAQVMEGAAIVDLPELGGSEKLRASGLKLFTLLDFAG
H