Protein Info for GFF2435 in Methylophilus sp. DMC18

Annotation: Molybdenum cofactor guanylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 192 TIGR02665: molybdenum cofactor guanylyltransferase" amino acids 3 to 186 (184 residues), 229.6 bits, see alignment E=1.5e-72 PF12804: NTP_transf_3" amino acids 5 to 165 (161 residues), 134.1 bits, see alignment E=2.7e-43

Best Hits

KEGG orthology group: K03752, molybdopterin-guanine dinucleotide biosynthesis protein A (inferred from 49% identity to tmz:Tmz1t_3716)

Predicted SEED Role

"Molybdopterin-guanine dinucleotide biosynthesis protein MobA" in subsystem Molybdenum cofactor biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (192 amino acids)

>GFF2435 Molybdenum cofactor guanylyltransferase (Methylophilus sp. DMC18)
MQITAVILAGGRGLRMGGVDKGLVDYQGKPLVAHVLERIQPQVNHVIINANRHLDEYQRF
GIPVVADANDQFDGPLAGMQAGMHHASTEWIVSVPCDSPLLPLDLVSRLKTALEQTQHLH
KHANGLAIARSQSGTHPVFCLMPRALREDLDHFLEQGQRKVSAWQAQHPHVFVSFEDEQA
FTNINERPSSSL