Protein Info for GFF2432 in Methylophilus sp. DMC18

Annotation: Adaptive-response sensory-kinase SasA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 493 transmembrane" amino acids 28 to 49 (22 residues), see Phobius details amino acids 196 to 214 (19 residues), see Phobius details PF00672: HAMP" amino acids 221 to 267 (47 residues), 37.7 bits, see alignment 3.2e-13 PF00512: HisKA" amino acids 283 to 340 (58 residues), 35.5 bits, see alignment 1.3e-12 PF02518: HATPase_c" amino acids 390 to 492 (103 residues), 58.7 bits, see alignment E=1.1e-19

Best Hits

KEGG orthology group: None (inferred from 54% identity to mei:Msip34_2340)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (493 amino acids)

>GFF2432 Adaptive-response sensory-kinase SasA (Methylophilus sp. DMC18)
MLFKRKQTSSSPHWQHDKPLRLLLLFHDIYFIALIVLAVASGAYGIYLWDKASKQSQRIN
VVIQEIYLVRGDLYRQMKELFDAFFLQETNALNEYNQYTTSILIHMERLQSIALDQEERD
ALMEIEHKYRNLVNEAPALFYRYQNNPDRNAQKSIYQDIETGIFKHYEEVSKRAERLLMI
KQGEIKHRLDEARSNSIAVLSLPLLLACVLIVYSRRILKESIVRPINDIMQATNAISGGS
LTHQVPEAGAEELAMLSREINKMAEDLAASRDALVKSEKQAALGLLVPMLAHNIRNPLAS
IRATAQVIDDPQLDKDTMESIQGIIHTVDRLERWTGSLLSYLHPIKPMLNQLRLSNIVQG
AVTTLHPKLNEKQIRLQENSDTVQQLILTDEHLLEQMLYNLLLNATEASPKGAEIQLQCA
LHDHLLTLVIIDQGPGMPFKPDPHALTPGPTTKRFGTGLGIPFAFKVCEELGGSMSFESG
AGTGTRITILLPQ