Protein Info for GFF2431 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Chaperone protein HscA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 TIGR01991: Fe-S protein assembly chaperone HscA" amino acids 21 to 615 (595 residues), 897.5 bits, see alignment E=2e-274 PF00012: HSP70" amino acids 22 to 600 (579 residues), 683.7 bits, see alignment E=2e-209 PF06723: MreB_Mbl" amino acids 122 to 373 (252 residues), 57.2 bits, see alignment E=1.3e-19

Best Hits

Swiss-Prot: 100% identical to HSCA_SALG2: Chaperone protein HscA (hscA) from Salmonella gallinarum (strain 287/91 / NCTC 13346)

KEGG orthology group: K04044, molecular chaperone HscA (inferred from 95% identity to cko:CKO_00255)

MetaCyc: 94% identical to iron-sulfur cluster biosynthesis chaperone HscA (Escherichia coli K-12 substr. MG1655)
3.6.4.-

Predicted SEED Role

"Chaperone protein HscA" in subsystem Protein chaperones

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (616 amino acids)

>GFF2431 Chaperone protein HscA (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLPDHEGRHLLPSVVHYQ
QQGHTVGYAARDNAAQDTANTISSVKRMMGRSLADIQTRYPHLPYRFKASVNGLPMIDTA
AGLLNPVRVSADILKALAARASESLSGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVL
RLLNEPTAAAIAYGLDSGKEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDD
FDHLLADYIREQAGIADRSDNRVQRELLDAAIAAKIALSDADTVRVNVAGWQGEITREQF
NDLISALVKRTLLACRRALKDAGVEPQDVLEVVMVGGSTRVPLVRERVGEFFGRTPLTAI
DPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARA
QDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPPLPAGGAHIRVTFQVDADGL
LSVTAMEKSTGVEASIQVKPSYGLTDGEIASMIKDSMSFAEQDVKARMLAEQKVEAARVL
ESLTGALTADAALLSAAERQCIDDAAAHLSAVAQGDDVDAIEQAIKNVDKQTQEFAARRM
DQSVRRALKGHSVDEV